N-(5-tert-butyl-4-{[(6R)-4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-6-(1-methylethyl)-2-oxotetrahydro-2H-pyran-3-yl]sulfanyl}-2-methylphenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide (non-preferred name)

Base Information

• Chemical Name: N-(5-tert-butyl-4-{[(6R)-4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-6-(1-methylethyl)-2-oxotetrahydro-2H-pyran-3-yl]sulfanyl}-2-methylphenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide (non-preferred name)
• CAS No.: 263842-60-0
• Molecular Formula: C₃₃H₃₇F₃N₂O₆S₂
• Molecular Weight: 678.794

Synonyms:

Chemical Property of N-(5-tert-butyl-4-{[(6R)-4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-6-(1-methylethyl)-2-oxotetrahydro-2H-pyran-3-yl]sulfanyl}-2-methylphenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide (non-preferred name)

Chemical Property:

• Vapor Pressure: 5.57E-25mmHg at 25°C
• Boiling Point: 770.6°C at 760 mmHg
• Flash Point: 419.8°C
• Density: 1.37g/cm³

Purity/Quality:

Safty Information:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-tert-butyl-4-{[(6R)-4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-6-(1-methylethyl)-2-oxotetrahydro-2H-pyran-3-yl]sulfanyl}-2-methylphenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide (non-preferred name)

There total 11 articles about N-(5-tert-butyl-4-{[(6R)-4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-6-(1-methylethyl)-2-oxotetrahydro-2H-pyran-3-yl]sulfanyl}-2-methylphenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide (non-preferred name) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-hydroxy-6-[2-(4-hydroxy-phenyl)ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one (207736-87-6) + toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester (261709-55-1) → 5-trifluoromethyl-pyridine-2-sulfonic acid (5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methyl-phenyl)-amide (263842-59-7,263842-60-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm990281p

Reference yield: 42.0%

(R)-4-hydroxy-6-[2-(4-hydroxy-phenyl)ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one (260258-03-5) + toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester (261709-55-1) → (R)-N-(5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methylphenyl)-2-(5-trifluoromethylpyridine)sulfonamide (263842-59-7,263842-60-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm990281p

Reference yield: 38.0%

5-trifluoromethyl-pyridin-2-ylsulfonylchloride (174485-72-4) + (S) 3-(4-Amino-2-tert-butyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one (207736-06-9) → (S)-N-(5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methylphenyl)-2-(5-trifluoromethylpyridine)sulfonamide (263842-59-7,263842-60-0)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1021/jm990281p

upstream raw materials:

5-trifluoromethyl-pyridin-2-ylsulfonylchloride

(S) 3-(4-Amino-2-tert-butyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one

2-mercapto-5-trifluoromethylpyridine

(S)-4-hydroxy-6-[2-(4-hydroxy-phenyl)ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one

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