2-Aminobenzhydrazide

Base Information

• Chemical Name: 2-Aminobenzhydrazide
• CAS No.: 1904-58-1
• Deprecated CAS: 46004-62-0
• Molecular Formula: C7H9N3O
• Molecular Weight: 151.168
• Hs Code.: 29280090
• European Community (EC) Number: 217-604-7
• NSC Number: 642
• DSSTox Substance ID: DTXSID5062051
• Nikkaji Number: J141.308B
• Wikidata: Q69757918
• ChEMBL ID: CHEMBL126038
• Mol file: 1904-58-1.mol

Synonyms:2-Aminobenzhydrazide;1904-58-1;2-Aminobenzohydrazide;o-Aminobenzhydrazide;Benzoic acid, 2-amino-, hydrazide;Anthranilic acid hydrazide;Anthraniloyl Hydrazine;Anthranilic hydrazide;Anthraniloyl hydrazide;2-Aminobenzoylhydrazine;2-Aminobenzoic acid hydrazide;o-Aminobenzoic hydrazide;Anthranilohydrazide;o-Aminobenzoic acid hydrazide;2-Aminobenzoylhydrazide;NSC 642;MFCD00017056;2-Amino-benzoic acid hydrazide;CHEMBL126038;EINECS 217-604-7;anthraniloylhydrazine;o-aminobenzoylhydrazine;o-Aminobenzoylhydrazide;2NPhCON2;2-aminobenzoic hydrazide;2-Aminobenzohydrazide #;2-Aminobenzoyl hydrazide;AMINO BENZHYDRAZIDE;2-Aminobenzhydrazide, 97%;1-(2-Aminobenzoyl)hydrazine;SCHEMBL112991;2-Aminobenzoic acid, hydrazide;NSC642;2-aminobenzene-1-carbohydrazide;DTXSID5062051;GRWMSCBKWMQPON-UHFFFAOYSA-;NSC-642;AC7791;BBL008412;BDBM50056892;STK011375;AKOS000305692;MS-1089;2-aminobenzohydrazide;SY040605;A1100;CS-0149901;FT-0611229;EN300-03742;A813408;AC-907/25014182;J-012295;Z104472510

Chemical Property of 2-Aminobenzhydrazide

Chemical Property:

• Appearance/Colour: light brown fine crystalline powder
• Melting Point: 121-125 °C(lit.)
• Refractive Index: 1.641
• Boiling Point: 273.17°C (rough estimate)
• PKA: pK1: 1.85;pK2: 3.47;pK3: 12.80 (25°C)
• PSA: 81.14000
• Density: 1.267 g/cm³
• LogP: 1.54470
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Light Sensitive
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 151.074561919
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

99% ^*data from raw suppliers

2-Aminobenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Hydrazides
• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NN)N

Technology Process of 2-Aminobenzhydrazide

There total 16 articles about 2-Aminobenzhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-ethoxycarbonylaniline (87-25-2) → anthranilic acid hydrazide (1904-58-1)

Guidance literature:

With hydrazine hydrate; In ethanol; water; Reflux;

DOI:10.1016/j.bmc.2015.06.051

Reference yield: 93.0%

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → anthranilic acid hydrazide (1904-58-1)

Guidance literature:

anthranilic acid; With sulfuric acid; In ethanol; for 6h; Reflux;

With hydrazine hydrate; sodium hydrogencarbonate; acetic acid; Reflux;

DOI:10.1016/j.ejmech.2017.06.036

Reference yield: 85.0%

2-carbomethoxyaniline (134-20-3) → anthranilic acid hydrazide (1904-58-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Reflux;

upstream raw materials:

isatoic anhydride

N³-n-butylquinazolin-4-one

2-carbomethoxyaniline

2-ethoxycarbonylaniline

Downstream raw materials:

acetylhydrazide de l'acide anthranilique

1-(2'-aminobenzoyl)-2-benzoylhydrazine

N-benzoyl-N'-(N-benzoyl-anthraniloyl)-hydrazine

N'-anthraniloyl-formohydrazonic acid ethyl ester

Refernces

• 1、 Shakhidoyatov,Urakov,Mukarramov,Ashirmatov,Bruskov. "Oxidative cyclocondensation of thio(seleno)-amides and ureas 1. 2-thioxo-4-quinazolone". . p. 728 - 731. Retrieved 1996.
• 2、 Liu, Zengchen,Li, Shujing,Ge, Genwu,Li, Yanxia,Zhao, Chunxiang,Zhang, Hui,Yang, Zhiguang. "A novel nitrogen heterocycle platform-based highly selective and sensitive fluorescence chemosensor for the detection of Al3+ and its application in cell imaging". . p. 5377 - 5383. Retrieved 2019.
• 3、 Bathini, Pavan Kumar,Yerrabelly, Hemasri,Yerrabelly, Jayaprakash Rao. "Synthesis and anti-microbial / anti-malarial activity of a new class of chromone-dihydroquinazolinone hybrid heterocycles". . p. 212 - 228. Retrieved 2018.
• 4、 Ikram, Muhammad,Rehman, Sadia,Ullah, Farhat,Akhtar, Gul. "Synthesis, physicochemical, and biological studies of complexes of 2-Aminobenzohydrazine with Co(II), ni(II), Cu(II), and zn(II) chlorides". . p. 847 - 854. Retrieved 2010.
• 5、 Gup, Ramazan,Kirkan, Buelent. "Synthesis and spectroscopic studies of mixed-ligand and polymeric dinuclear transition metal complexes with bis-acylhydrazone tetradentate ligands and 1,10-phenanthroline". . p. 809 - 815. Retrieved 2006.
• 6、 Liu, Qingqing,Zhang, Bin,Wang, Yuanjiang,Wang, Xinyi,Gou, Shaohua. "Discovery of phthalazino[1,2-b]-quinazolinone derivatives as multi-target HDAC inhibitors for the treatment of hepatocellular carcinoma via activating the p53 signal pathway". . . Retrieved 2021/12/30.
• 7、 Zhou, Wenjuan,Xu, Chenhao,Dong, Guanjun,Qiao, Hui,Yang, Jing,Liu, Hongmin,Ding, Lina,Sun, Kai,Zhao, Wen. "Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction". . . Retrieved 2021/03/24.