methyl 2-(4-chloro-6-phenyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

Base Information

Chemical Name:methyl 2-(4-chloro-6-phenyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate
CAS No.:1265402-72-9
Molecular Formula:C₂₁H₂₆ClN₃O₂
Molecular Weight:387.909
Hs Code.:

Synonyms:methyl 2-(4-chloro-6-phenyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

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Chemical Property of methyl 2-(4-chloro-6-phenyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

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Technology Process of methyl 2-(4-chloro-6-phenyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

There total 5 articles about methyl 2-(4-chloro-6-phenyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1265402-67-2
methyl 2-(6-oxo-4-phenyl-2-(piperidin-1-yl)-1,6-dihydropyrimidin-5-yl)pentanoate

: 1265402-72-9
methyl 2-(4-chloro-6-phenyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

Guidance literature:: With N,N-dimethyl-aniline; trichlorophosphate; In toluene; for 3h; Inert atmosphere; Reflux;

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 1265402-72-9
methyl 2-(4-chloro-6-phenyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: sodium methylate; methanol / 21 h / Reflux

3: thionyl chloride / 18 h / Reflux

4: trichlorophosphate; N,N-dimethyl-aniline / toluene / 3 h / Inert atmosphere; Reflux

With methanol; thionyl chloride; sodium methylate; potassium carbonate; N,N-dimethyl-aniline; trichlorophosphate; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 615-83-8
2-bromo-pentanoic acid ethyl ester

: 1265402-72-9
methyl 2-(4-chloro-6-phenyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: sodium methylate; methanol / 21 h / Reflux

3: thionyl chloride / 18 h / Reflux

4: trichlorophosphate; N,N-dimethyl-aniline / toluene / 3 h / Inert atmosphere; Reflux

With methanol; thionyl chloride; sodium methylate; potassium carbonate; N,N-dimethyl-aniline; trichlorophosphate; In N,N-dimethyl-formamide; toluene;