(4S,14S)-19-Bromo-21-methoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene

Base Information

• Chemical Name: (4S,14S)-19-Bromo-21-methoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene
• CAS No.: 189451-78-3
• Molecular Formula: C₂₉H₃₃BrO₆
• Molecular Weight: 557.481
• Mol file: 189451-78-3.mol

Synonyms:(4S,14S)-19-Bromo-21-methoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene

Chemical Property of (4S,14S)-19-Bromo-21-methoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,14S)-19-Bromo-21-methoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene

There total 2 articles about (4S,14S)-19-Bromo-21-methoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5-bromo-1,3-bis(bromomethyl)-2-methoxybenzene (118249-11-9) + (S,S)-(+)-1,11-diphenyl-3,6,9-trioxaundecane-1,11-diol (93417-23-3) → (4S,14S)-19-Bromo-21-methoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1(20),17(21),18-triene (189451-78-3)

Guidance literature:

With sodium hydride; potassium tetrafluoroborate; In tetrahydrofuran; for 22h; Heating;

DOI:10.1016/S0957-4166(97)00047-5

Reference yield:

C30H42O7 → (4S,14S)-19-Bromo-21-methoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1(20),17(21),18-triene (189451-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / ethanol / 7 h / 60 °C

2: 67 percent / NaH, KBF₄ / tetrahydrofuran / 22 h / Heating

With pyridinium p-toluenesulfonate; sodium hydride; potassium tetrafluoroborate; In tetrahydrofuran; ethanol;

DOI:10.1016/S0957-4166(97)00047-5

Reference yield: 96.0%

(4S,14S)-19-Bromo-21-methoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1(20),17(21),18-triene (189451-78-3) → (4S,14S)-19-Bromo-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1(20),17(21),18-trien-21-ol (189451-74-9)

Guidance literature:

With sodium hydride; ethanethiol; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

DOI:10.1016/S0957-4166(97)00047-5

upstream raw materials:

5-bromo-1,3-bis(bromomethyl)-2-methoxybenzene

(S,S)-(+)-1,11-diphenyl-3,6,9-trioxaundecane-1,11-diol

Downstream raw materials:

(4S,14S)-19-Bromo-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-trien-21-ol

(4S,14S)-21-Methoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene

(4S,14S)-4,14-Diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-trien-21-ol

(4S,14S)-19-Bromo-21-methoxymethoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene