2'-(2,2,2-trichloroethoxycarbonyl)-7-(3-methyl-3-sulfanylbutyryl)paclitaxel

Base Information

Chemical Name:2'-(2,2,2-trichloroethoxycarbonyl)-7-(3-methyl-3-sulfanylbutyryl)paclitaxel
CAS No.:382601-30-1
Molecular Formula:C₅₅H₆₀Cl₃NO₁₇S
Molecular Weight:1145.5
Hs Code.:

Synonyms:2'-(2,2,2-trichloroethoxycarbonyl)-7-(3-methyl-3-sulfanylbutyryl)paclitaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-(2,2,2-trichloroethoxycarbonyl)-7-(3-methyl-3-sulfanylbutyryl)paclitaxel

Chemical Property:

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Technology Process of 2'-(2,2,2-trichloroethoxycarbonyl)-7-(3-methyl-3-sulfanylbutyryl)paclitaxel

There total 5 articles about 2'-(2,2,2-trichloroethoxycarbonyl)-7-(3-methyl-3-sulfanylbutyryl)paclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 382601-29-8
2'-(2,2,2-trichloroethoxycarbonyl)-7-[3-methyl-3-(2,4,6-trimethoxyphenylmethylsulfanyl)butyryl]paclitaxel

: 382601-30-1
2'-(2,2,2-trichloroethoxycarbonyl)-7-(3-methyl-3-sulfanylbutyryl)paclitaxel

Guidance literature:: With formic acid; L-Cysteine; In dichloromethane; at 20 ℃; for 0.666667h;
DOI:10.1021/jm0304111

Reference yield:

: 59729-24-7
3-mercapto-3-methylbutanoic acid

: 382601-30-1
2'-(2,2,2-trichloroethoxycarbonyl)-7-(3-methyl-3-sulfanylbutyryl)paclitaxel

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / trifluoroacetic acid / CH₂Cl₂ / 5 °C

2: 67 percent / 4-(dimethylamino)pyridine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl / CH₂Cl₂ / 20 °C

3: 73 percent / L-cysteine; HCO₂H / CH₂Cl₂ / 0.67 h / 20 °C

With dmap; formic acid; L-Cysteine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm0304111

Reference yield:

: 100431-55-8
2'-<<(trichloroethyl)oxy>carbonyl>taxol

: 382601-30-1
2'-(2,2,2-trichloroethoxycarbonyl)-7-(3-methyl-3-sulfanylbutyryl)paclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / 4-(dimethylamino)pyridine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl / CH₂Cl₂ / 20 °C

2: 73 percent / L-cysteine; HCO₂H / CH₂Cl₂ / 0.67 h / 20 °C

With dmap; formic acid; L-Cysteine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jm0304111