100431-55-8Relevant articles and documents
Combination of Paclitaxel and Nitric Oxide as a Novel Treatment for the Reduction of Restenosis
Lin, Chia-En,Garvey, David S.,Janero, David R.,Letts, L. Gordon,Marek, Przemyslaw,Richardson, Stewart K.,Serebryanik, Diana,Shumway, Matthew J.,Tam, S. William,Trocha, A. Mark,Young, Delano V.
, p. 2276 - 2282 (2007/10/03)
The combination of a nitric oxide (NO) donor and a paclitaxel-NO donor conjugate coated on a vascular stent was tested in a rabbit iliac artery model of stenosis as a potential therapy for restenosis. Paclitaxel was conjugated with a NO donor at the 7-pos
Synthesis and evaluation of some water-soluble prodrugs and derivatives of taxol with antitumor activity
Mathew,Mejillano,Nath,Himes,Stella
, p. 145 - 151 (2007/10/02)
The synthesis and evaluation of some 2'- and 7-amino acid derivatives of taxol (1) are reported. Reaction of taxol with N-protected amino acids gave 2'-N-protected amino acid esters of taxol. However, deprotection of the amino group and subsequent isolati
Modified Taxols. 2. Oxidation Products of Taxol
Magri, Neal F.,Kingston, David G. I.
, p. 797 - 802 (2007/10/02)
Oxidation of taxol (1) or substituted taxols with Jones' reagent under appropriate conditions yielded 7-oxotaxol (6), 2',7'-dioxotaxol (9), or 2'-oxo-7-acetyltaxol (12).Treatment of 7-oxotaxol with DBU or silica gel yielded a D-secotaxol derivative 14.Hydrogenation of the 2'-acetate derivative of 14 yielded the unstable diketone 16, while hydrogenation of 14 itself followed by workup in methanol gave the lactone 17.