3(R),4(S)-dihydroxy-5(R)-(1'(S),2'-dihydroxyethyl)-(S)-cyclohexanecarboxylic acid

Base Information

Chemical Name:3(R),4(S)-dihydroxy-5(R)-(1'(S),2'-dihydroxyethyl)-(S)-cyclohexanecarboxylic acid
CAS No.:128244-13-3
Molecular Formula:C₉H₁₆O₆
Molecular Weight:220.222
Hs Code.:

Synonyms:3(R),4(S)-dihydroxy-5(R)-(1'(S),2'-dihydroxyethyl)-(S)-cyclohexanecarboxylic acid

Suppliers and Price of 3(R),4(S)-dihydroxy-5(R)-(1'(S),2'-dihydroxyethyl)-(S)-cyclohexanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3(R),4(S)-dihydroxy-5(R)-(1'(S),2'-dihydroxyethyl)-(S)-cyclohexanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3(R),4(S)-dihydroxy-5(R)-(1'(S),2'-dihydroxyethyl)-(S)-cyclohexanecarboxylic acid

There total 26 articles about 3(R),4(S)-dihydroxy-5(R)-(1'(S),2'-dihydroxyethyl)-(S)-cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 128244-21-3
tert-butyl 3(R),4(S)-O-isopropylidene-5(R)-((1'S)-3',3'-dimethyl-2',4'-dioxolanyl)-(S)-cyclohexanecarboxylate

: 128244-13-3
3(R),4(S)-dihydroxy-5(R)-(1'(S),2'-dihydroxyethyl)-(S)-cyclohexanecarboxylic acid

Guidance literature:: With trifluoroacetic acid; at 0 ℃; for 0.666667h;
DOI:10.1021/jo00302a040

Reference yield: 95.0%

: 128244-22-4
tert-butyl 3(R),4(S)-O-isopropylidene-5(R)-((1'S)-3',3'-dimethyl-2',4'-dioxolanyl)-(R)-cyclohexanecarboxylate

: 128244-13-3,128300-98-1
3(R),4(S)-dihydroxy-5(R)-(1'(S),2'-dihydroxyethyl)-(R)-cyclohexanecarboxylic acid

Guidance literature:: With trifluoroacetic acid; at 0 ℃; for 0.666667h;
DOI:10.1021/jo00302a040

Reference yield:

: 3969-61-7
2,3,5,6-di-isopropyIidene-1,4-dihydroxy-D-mannitol

: 128244-13-3
3(R),4(S)-dihydroxy-5(R)-(1'(S),2'-dihydroxyethyl)-(S)-cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 8.98 g / pyridine / 6 h / Ambient temperature

2: pyridine / Ambient temperature

3: toluene / 6 h / 75 - 85 °C / Irradiation

4: tetraethylammonium fluoride / tetrahydrofuran / 4 h / 50 °C

5: 90 percent / imidazole, triphenylphosphine, iodine / toluene / 2 h / Heating

6: 1) BH₃-SMe₃ 2) aq. NaOH, 30 percent H₂O₂ / 1) CH₂Cl₂, RT, 1.5 h , 2) ethanol

7: 65 percent / PDC, acetic anhydride / CH₂Cl₂ / 3 h / Heating

8: 68 percent / LDA / tetrahydrofuran; cyclohexane / -75 deg C to RT, overnight

9: 96 percent / aq. trifluoroacetic acid / 0.67 h / 0 °C

With pyridine; 1H-imidazole; sodium hydroxide; dipyridinium dichromate; dimethylsulfide borane complex; dihydrogen peroxide; iodine; acetic anhydride; tetraethylammonium fluoride; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; cyclohexane; toluene;
DOI:10.1021/jo00302a040