(R)-4-([1,4'-bipiperidin]-1'-yl)-2-amino-4-oxo-N-((R)-1-phenylethyl)butanamide

Base Information

Chemical Name:(R)-4-([1,4'-bipiperidin]-1'-yl)-2-amino-4-oxo-N-((R)-1-phenylethyl)butanamide
CAS No.:1361214-55-2
Molecular Formula:C₂₂H₃₄N₄O₂
Molecular Weight:386.538
Hs Code.:

Synonyms:(R)-4-([1,4'-bipiperidin]-1'-yl)-2-amino-4-oxo-N-((R)-1-phenylethyl)butanamide

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Chemical Property of (R)-4-([1,4'-bipiperidin]-1'-yl)-2-amino-4-oxo-N-((R)-1-phenylethyl)butanamide

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Technology Process of (R)-4-([1,4'-bipiperidin]-1'-yl)-2-amino-4-oxo-N-((R)-1-phenylethyl)butanamide

There total 4 articles about (R)-4-([1,4'-bipiperidin]-1'-yl)-2-amino-4-oxo-N-((R)-1-phenylethyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1361214-54-1
benzyl ((R)-4-([1,4'-bipiperidin]-1'-yl)-1,4-dioxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate

: 1361214-55-2
(R)-4-([1,4'-bipiperidin]-1'-yl)-2-amino-4-oxo-N-((R)-1-phenylethyl)butanamide

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In methanol; for 18h;
DOI:10.1016/j.bmc.2011.12.013

Reference yield:

: 512785-11-4
N-[(benzyloxy)carbonyl]-D-aspartic acid β-tert-butyl ester α-[(R)-α-methylbenzyl]amide

: 1361214-55-2
(R)-4-([1,4'-bipiperidin]-1'-yl)-2-amino-4-oxo-N-((R)-1-phenylethyl)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: formic acid / 3 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

3: 5%-palladium/activated carbon; hydrogen / methanol / 18 h

With formic acid; 5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2011.12.013

Reference yield:

: 1361214-53-0
(R)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid

: 1361214-55-2
(R)-4-([1,4'-bipiperidin]-1'-yl)-2-amino-4-oxo-N-((R)-1-phenylethyl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 18 h

With 5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2011.12.013