benzyl ((R)-4-([1,4'-bipiperidin]-1'-yl)-1,4-dioxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate

Base Information

• Chemical Name: benzyl ((R)-4-([1,4'-bipiperidin]-1'-yl)-1,4-dioxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate
• CAS No.: 1361214-54-1
• Molecular Formula: C₃₀H₄₀N₄O₄
• Molecular Weight: 520.672
• Mol file: 1361214-54-1.mol

Synonyms:benzyl ((R)-4-([1,4'-bipiperidin]-1'-yl)-1,4-dioxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate

Chemical Property of benzyl ((R)-4-([1,4'-bipiperidin]-1'-yl)-1,4-dioxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl ((R)-4-([1,4'-bipiperidin]-1'-yl)-1,4-dioxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate

There total 4 articles about benzyl ((R)-4-([1,4'-bipiperidin]-1'-yl)-1,4-dioxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-piperidinopiperidin (4897-50-1) + (R)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid (1361214-53-0) → benzyl ((R)-4-([1,4'-bipiperidin]-1'-yl)-1,4-dioxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate (1361214-54-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.bmc.2011.12.013

Reference yield:

N-[(benzyloxy)carbonyl]-D-aspartic acid β-tert-butyl ester α-[(R)-α-methylbenzyl]amide (512785-11-4) → benzyl ((R)-4-([1,4'-bipiperidin]-1'-yl)-1,4-dioxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate (1361214-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid / 3 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

With formic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1016/j.bmc.2011.12.013

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → benzyl ((R)-4-([1,4'-bipiperidin]-1'-yl)-1,4-dioxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate (1361214-54-1)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2: formic acid / 3 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

With formic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1016/j.bmc.2011.12.013

upstream raw materials:

N-[(benzyloxy)carbonyl]-D-aspartic acid β-tert-butyl ester α-[(R)-α-methylbenzyl]amide

4-piperidinopiperidin

(R)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

(R)-4-([1,4'-bipiperidin]-1'-yl)-2-amino-4-oxo-N-((R)-1-phenylethyl)butanamide