[6-chloro-3-(3,5-dimethyl-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-acetonitrile

Base Information

Chemical Name:[6-chloro-3-(3,5-dimethyl-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-acetonitrile
CAS No.:890524-76-2
Molecular Formula:C₁₅H₁₄ClN₃O₂
Molecular Weight:303.748
Hs Code.:

[6-chloro-3-(3,5-dimethyl-benzyl)-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl]-acetonitrile

Synonyms:[6-chloro-3-(3,5-dimethyl-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-acetonitrile

Suppliers and Price of [6-chloro-3-(3,5-dimethyl-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [6-chloro-3-(3,5-dimethyl-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [6-chloro-3-(3,5-dimethyl-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-acetonitrile

There total 3 articles about [6-chloro-3-(3,5-dimethyl-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 890524-75-1
(6-chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetonitrile

: 27129-87-9
3,5-dimethylbenzyl alcohol

: 890524-76-2
[6-chloro-3-(3,5-dimethyl-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-acetonitrile

Guidance literature:: With diamide; triphenylphosphine; In tetrahydrofuran; at 50 ℃; for 5h;
DOI:10.1248/cpb.54.325

Reference yield:

: 1453172-27-4
6-chloro-1-methoxymethyl-3-(3,5-dimethylbenzyl)uracil

: 590-17-0
cyanomethyl bromide

: 890524-76-2
[6-chloro-3-(3,5-dimethyl-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-acetonitrile

: C₁₅H₁₄BrN₃O₂

Guidance literature:: 6-chloro-1-methoxymethyl-3-(3,5-dimethylbenzyl)uracil; With bromocatecholborane; In dichloromethane; at 20 ℃; for 2h;

cyanomethyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2013.06.061

Reference yield:

: 228396-40-5
1-methoxymethyl-6-chlorouracil

: 890524-76-2
[6-chloro-3-(3,5-dimethyl-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diamide / tetrahydrofuran / 2 h / 50 °C

2.1: bromocatecholborane / dichloromethane / 2 h / 20 °C

2.2: 20 °C / Inert atmosphere

With diamide; bromocatecholborane; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1.1: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2013.06.061