2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(1-methyl-5-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

Base Information

Chemical Name:2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(1-methyl-5-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate
CAS No.:1360056-59-2
Molecular Formula:C₃₆H₃₈FN₇O₄
Molecular Weight:651.741
Hs Code.:

2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(1-methyl-5-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

Synonyms:2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(1-methyl-5-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

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Chemical Property of 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(1-methyl-5-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

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Technology Process of 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(1-methyl-5-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

There total 7 articles about 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(1-methyl-5-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242156-76-8
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

: 1360056-58-1
6-chloro-2-methyl-4-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)pyridazin-3(2H)-one

: 1360055-28-2
6-tert-butyl-8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(1-methyl-pyrrolidin-3-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

: 1360056-59-2
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(1-methyl-5-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

Guidance literature:: With potassium phosphate; XPhos; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In water; butan-1-ol; at 110 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 630121-86-7
3-(((trifluoromethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylic acid tert-butyl ester

: 1360055-28-2
6-tert-butyl-8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(1-methyl-pyrrolidin-3-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

: 1360056-59-2
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(1-methyl-5-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / methanol / 36 h

3.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

4.1: formic acid; formaldehyd / water / 18 h / 70 °C

4.2: pH 14

5.1: potassium phosphate; XPhos / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / 1.5 h / 110 °C / Inert atmosphere

With potassium phosphate; formaldehyd; formic acid; hydrogen; potassium carbonate; caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; butan-1-ol;

Reference yield:

: 101385-93-7
3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1360055-28-2
6-tert-butyl-8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(1-methyl-pyrrolidin-3-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

: 1360056-59-2
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(1-methyl-5-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

1.2: -78 - 20 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

3.1: hydrogen / palladium on activated charcoal / methanol / 36 h

4.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

5.1: formic acid; formaldehyd / water / 18 h / 70 °C

5.2: pH 14

6.1: potassium phosphate; XPhos / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / 1.5 h / 110 °C / Inert atmosphere

With potassium phosphate; formaldehyd; formic acid; hydrogen; potassium carbonate; caesium carbonate; lithium hexamethyldisilazane; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; butan-1-ol;