4-[4-(4-chloro-benzyl)-piperazin-1-ylmethyl]-naphthalene-1-carbaldehyde

Base Information

Chemical Name:4-[4-(4-chloro-benzyl)-piperazin-1-ylmethyl]-naphthalene-1-carbaldehyde
CAS No.:1026257-19-1
Molecular Formula:C₂₃H₂₃ClN₂O
Molecular Weight:378.901
Hs Code.:

Synonyms:4-[4-(4-chloro-benzyl)-piperazin-1-ylmethyl]-naphthalene-1-carbaldehyde

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Chemical Property of 4-[4-(4-chloro-benzyl)-piperazin-1-ylmethyl]-naphthalene-1-carbaldehyde

Chemical Property:

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Technology Process of 4-[4-(4-chloro-benzyl)-piperazin-1-ylmethyl]-naphthalene-1-carbaldehyde

There total 6 articles about 4-[4-(4-chloro-benzyl)-piperazin-1-ylmethyl]-naphthalene-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(4-chloro-benzyl)-4-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-naphthalen-1-ylmethyl]-piperazine

: 1026257-19-1
4-[4-(4-chloro-benzyl)-piperazin-1-ylmethyl]-naphthalene-1-carbaldehyde

Guidance literature:: With pyridinium p-toluenesulfonate; In acetone; Heating;
DOI:10.1021/jm0208572

Reference yield:

: 23145-88-2
1-[(4-chlorophenyl)methyl]piperazine

: 1026257-19-1
4-[4-(4-chloro-benzyl)-piperazin-1-ylmethyl]-naphthalene-1-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaHCO₃ / acetonitrile / Heating

2: aq. pyridinium p-toluenesulfonic acid / acetone / Heating

With pyridinium p-toluenesulfonate; sodium hydrogencarbonate; In acetone; acetonitrile;
DOI:10.1021/jm0208572

Reference yield:

: 57322-45-9
1,4-dihydroxymethyl naphthalene

: 1026257-19-1
4-[4-(4-chloro-benzyl)-piperazin-1-ylmethyl]-naphthalene-1-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / MnO₂ / ethyl acetate / 0.75 h

2: 75 percent / 48percent aq. HBr; H₂SO₄ / 4 h

3: 65 percent / trimethyl orthoformate; p-TsOH / diethyl ether / 12 h / Heating

4: aq. NaHCO₃ / acetonitrile / Heating

5: aq. pyridinium p-toluenesulfonic acid / acetone / Heating

With manganese(IV) oxide; sulfuric acid; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; toluene-4-sulfonic acid; trimethyl orthoformate; In diethyl ether; ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm0208572