1-[2-(Methyl{6-[(4-methyl-5-{methyl[2-(methylamino)ethyl]carbamoyl}thiophen-2-yl)amino]hexanoyl}amino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate

Base Information

Chemical Name:1-[2-(Methyl{6-[(4-methyl-5-{methyl[2-(methylamino)ethyl]carbamoyl}thiophen-2-yl)amino]hexanoyl}amino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate
CAS No.:1246248-59-8
Molecular Formula:C₃₇H₅₂N₆O₄S
Molecular Weight:676.924
Hs Code.:

1-[2-(Methyl{6-[(4-methyl-5-{methyl[2-(methylamino)ethyl]carbamoyl}thiophen-2-yl)amino]hexanoyl}amino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate

Synonyms:1-[2-(Methyl{6-[(4-methyl-5-{methyl[2-(methylamino)ethyl]carbamoyl}thiophen-2-yl)amino]hexanoyl}amino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate

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Chemical Property of 1-[2-(Methyl{6-[(4-methyl-5-{methyl[2-(methylamino)ethyl]carbamoyl}thiophen-2-yl)amino]hexanoyl}amino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate

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Technology Process of 1-[2-(Methyl{6-[(4-methyl-5-{methyl[2-(methylamino)ethyl]carbamoyl}thiophen-2-yl)amino]hexanoyl}amino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate

There total 8 articles about 1-[2-(Methyl{6-[(4-methyl-5-{methyl[2-(methylamino)ethyl]carbamoyl}thiophen-2-yl)amino]hexanoyl}amino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1246248-58-7
1-(2-{[6-({5-[{2-[(tert-Butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

: 1246248-59-8
1-[2-(Methyl{6-[(4-methyl-5-{methyl[2-(methylamino)ethyl]carbamoyl}thiophen-2-yl)amino]hexanoyl}amino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: 1-(2-{[6-({5-[{2-[(tert-Butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate; With hydrogenchloride; In methanol; at 20 ℃; for 2h;

With sodium hydroxide; In water; ethyl acetate; pH=10;

Reference yield:

: 1246248-56-5
tert-Butyl {2-[({5-[(tert-butoxycarbonyl)amino]-3-methylthiophen-2-yl}carbonyl)(methyl)amino]ethyl}methylcarbamate

: 1246248-59-8
1-[2-(Methyl{6-[(4-methyl-5-{methyl[2-(methylamino)ethyl]carbamoyl}thiophen-2-yl)amino]hexanoyl}amino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Cooling with ice

1.2: 2 h / 20 °C

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 °C

2.2: 1 h / 20 °C

3.1: hydrogenchloride / methanol / 2 h / 20 °C

3.2: pH 10

With hydrogenchloride; sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; In methanol; dichloromethane;

Reference yield:

: 22809-37-6
6-bromohexanoyl chloride

: 1246248-59-8
1-[2-(Methyl{6-[(4-methyl-5-{methyl[2-(methylamino)ethyl]carbamoyl}thiophen-2-yl)amino]hexanoyl}amino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.33 h / 20 °C / Cooling with ice

1.2: 15.5 h / 60 °C

1.3: 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1 h / 20 °C / Cooling with ice

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 °C

3.2: 1 h / 20 °C

4.1: hydrogenchloride / methanol / 2 h / 20 °C

4.2: pH 10

With hydrogenchloride; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; dimethyl sulfoxide;