1-(2-{[6-({5-[{2-[(tert-Butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Base Information

Chemical Name:1-(2-{[6-({5-[{2-[(tert-Butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate
CAS No.:1246248-58-7
Molecular Formula:C₄₂H₆₀N₆O₆S
Molecular Weight:777.041
Hs Code.:

1-(2-{[6-({5-[{2-[(tert-Butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Synonyms:1-(2-{[6-({5-[{2-[(tert-Butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

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Chemical Property of 1-(2-{[6-({5-[{2-[(tert-Butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

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Technology Process of 1-(2-{[6-({5-[{2-[(tert-Butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

There total 7 articles about 1-(2-{[6-({5-[{2-[(tert-Butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 864765-63-9
Biphenyl-2-ylcarbamic Acid 1-{2-[Methyl-(6-oxohexanoyl)-amino]ethyl}piperidin-4-yl Ester

: 1246248-57-6
tert-Butyl (2-{[(5-amino-3-methylthiophen-2-yl)carbonyl](methyl)amino}ethyl)methylcarbamate

: 1246248-58-7
1-(2-{[6-({5-[{2-[(tert-Butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Biphenyl-2-ylcarbamic Acid 1-{2-[Methyl-(6-oxohexanoyl)-amino]ethyl}piperidin-4-yl Ester; tert-Butyl (2-{[(5-amino-3-methylthiophen-2-yl)carbonyl](methyl)amino}ethyl)methylcarbamate; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 12h;

With sodium tetrahydroborate; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1246248-56-5
tert-Butyl {2-[({5-[(tert-butoxycarbonyl)amino]-3-methylthiophen-2-yl}carbonyl)(methyl)amino]ethyl}methylcarbamate

: 1246248-58-7
1-(2-{[6-({5-[{2-[(tert-Butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Cooling with ice

1.2: 2 h / 20 °C

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 °C

2.2: 1 h / 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 743460-48-2
biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester

: 1246248-58-7
1-(2-{[6-({5-[{2-[(tert-Butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.33 h / 20 °C / Cooling with ice

1.2: 15.5 h / 60 °C

1.3: 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1 h / 20 °C / Cooling with ice

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 °C

3.2: 1 h / 20 °C

With sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide;