(11S)-11-[(benzyloxy)methyl]-10,11-dihydro-8H-[1,4]oxazino[4',3':1,2]imidazo[4,5-c]quinoline

Base Information

Chemical Name:(11S)-11-[(benzyloxy)methyl]-10,11-dihydro-8H-[1,4]oxazino[4',3':1,2]imidazo[4,5-c]quinoline
CAS No.:898818-47-8
Molecular Formula:C₂₁H₁₉N₃O₂
Molecular Weight:345.401
Hs Code.:

Synonyms:(11S)-11-[(benzyloxy)methyl]-10,11-dihydro-8H-[1,4]oxazino[4',3':1,2]imidazo[4,5-c]quinoline

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Chemical Property of (11S)-11-[(benzyloxy)methyl]-10,11-dihydro-8H-[1,4]oxazino[4',3':1,2]imidazo[4,5-c]quinoline

Chemical Property:

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Technology Process of (11S)-11-[(benzyloxy)methyl]-10,11-dihydro-8H-[1,4]oxazino[4',3':1,2]imidazo[4,5-c]quinoline

There total 2 articles about (11S)-11-[(benzyloxy)methyl]-10,11-dihydro-8H-[1,4]oxazino[4',3':1,2]imidazo[4,5-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 898818-46-7
1-[(1S)-2-(benzyloxy)-1-({[tert-butyl(dimethyl)silyl]oxy}methyl)ethyl]-2-(chloromethyl)-1H-imidazo[4,5-c]quinoline

: 898818-47-8
(11S)-11-[(benzyloxy)methyl]-10,11-dihydro-8H-[1,4]oxazino[4',3':1,2]imidazo[4,5-c]quinoline

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; at -78 - 20 ℃;

Reference yield:

: 905574-66-5
(2R)-2-[(3-aminoquinolin-4-yl)amino]-3-(benzyloxy)propan-1-ol

: 79-04-9
chloroacetyl chloride

: 898818-47-8
(11S)-11-[(benzyloxy)methyl]-10,11-dihydro-8H-[1,4]oxazino[4',3':1,2]imidazo[4,5-c]quinoline

Guidance literature:: (2R)-2-[(3-aminoquinolin-4-yl)amino]-3-(benzyloxy)propan-1-ol; chloroacetyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

With acetic acid; for 6h; Heating / reflux;

With potassium carbonate; In ethanol; water; at 60 ℃; for 1h;

Reference yield:

: 898818-47-8
(11S)-11-[(benzyloxy)methyl]-10,11-dihydro-8H-[1,4]oxazino[4',3':1,2]imidazo[4,5-c]quinoline

: 898818-48-9
(11S)-11-[(benzyloxy)methyl]-10,11-dihydro-8H-[1,4]oxazino[4',3':1,2]imidazo[4,5-c]quinoline 5-oxide

Guidance literature:: (11S)-11-[(benzyloxy)methyl]-10,11-dihydro-8H-[1,4]oxazino[4',3':1,2]imidazo[4,5-c]quinoline; With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 ℃; for 18h;

With sodium hydrogencarbonate; In chloroform; water;