benzyl (3R,4S)-3-((tert-butoxycarbonyl)amino)-4-methylpyrrolidine-1-carboxylate

Base Information

Chemical Name:benzyl (3R,4S)-3-((tert-butoxycarbonyl)amino)-4-methylpyrrolidine-1-carboxylate
CAS No.:1610704-01-2
Molecular Formula:C₁₈H₂₆N₂O₄
Molecular Weight:334.415
Hs Code.:

Synonyms:benzyl (3R,4S)-3-((tert-butoxycarbonyl)amino)-4-methylpyrrolidine-1-carboxylate

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Chemical Property of benzyl (3R,4S)-3-((tert-butoxycarbonyl)amino)-4-methylpyrrolidine-1-carboxylate

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Technology Process of benzyl (3R,4S)-3-((tert-butoxycarbonyl)amino)-4-methylpyrrolidine-1-carboxylate

There total 4 articles about benzyl (3R,4S)-3-((tert-butoxycarbonyl)amino)-4-methylpyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1428243-36-0,1402666-47-0,1428243-71-3
(3R,4R)-1-(benzyloxycarbonyl)-4-methylpyrrolidin-3-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1610704-01-2
benzyl (3R,4S)-3-((tert-butoxycarbonyl)amino)-4-methylpyrrolidine-1-carboxylate

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; at 20 - 95 ℃; Temperature;

Reference yield:

: benzyl 3-((tert-butoxycarbonyl)amino)-4-methylpyrrolidine-1-carboxylate

: 1610704-01-2
benzyl (3R,4S)-3-((tert-butoxycarbonyl)amino)-4-methylpyrrolidine-1-carboxylate

: 1610704-00-1
(3S,4R)-3-tert-butoxycarbonyl-4-methylpyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With carbon dioxide; In methanol; Resolution of racemate;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1610704-01-2
benzyl (3R,4S)-3-((tert-butoxycarbonyl)amino)-4-methylpyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / water; tert-butyl methyl ether / 10 - 20 °C

2: potassium dihydrogenphosphate / tert-butyl methyl ether / 480 h / 20 °C / pH 7

3: triethylamine; diphenylphosphoranyl azide / 20 - 95 °C

With potassium dihydrogenphosphate; diphenylphosphoranyl azide; potassium carbonate; triethylamine; In tert-butyl methyl ether; water;