(2R,3S,4S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-4-methyl-octan-3-ol

Base Information

Chemical Name:(2R,3S,4S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-4-methyl-octan-3-ol
CAS No.:382139-12-0
Molecular Formula:C₃₈H₅₄O₅Si
Molecular Weight:618.929
Hs Code.:

Synonyms:(2R,3S,4S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-4-methyl-octan-3-ol

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Chemical Property of (2R,3S,4S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-4-methyl-octan-3-ol

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Technology Process of (2R,3S,4S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-4-methyl-octan-3-ol

There total 16 articles about (2R,3S,4S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-4-methyl-octan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 382138-89-8
(2S,3S,4R,5S,6S,8S)-8-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(4-methoxy-benzyloxy)-2,4,6-trimethyl-decane-3,5-diol

: 382139-12-0
(2R,3S,4S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-4-methyl-octan-3-ol

Guidance literature:: With 4 Angstroem MS; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 0 ℃; for 10h;
DOI:10.1002/1521-3773(20011001)40:19<3632::AID-ANIE3632>3.0.CO;2-5

Reference yield:

: 182193-69-7
(S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one

: 382139-12-0
(2R,3S,4S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-4-methyl-octan-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; tin(II) triflate / CH₂Cl₂ / 2 h / -78 °C

1.2: 2.30 g / CH₂Cl₂ / 5 h / -78 °C

2.1: 82 percent / Me₄NBH(OAc)3; AcOH / acetonitrile / -25 - 0 °C

3.1: 85 percent / DDQ; 4 Angstroem molecular sieves / CH₂Cl₂ / 5 h / 0 °C

With tin(II) trifluoromethanesulfonate; 4 A molecular sieve; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tetramethylammonium triacetoxyborohydride; In dichloromethane; acetonitrile;
DOI:10.1021/ja020091v

Reference yield:

: 253143-33-8
(2S,4S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexanal

: 382139-12-0
(2R,3S,4S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-4-methyl-octan-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; tin(II) triflate / CH₂Cl₂ / 2 h / -78 °C

1.2: 2.30 g / CH₂Cl₂ / 5 h / -78 °C

2.1: 82 percent / Me₄NBH(OAc)3; AcOH / acetonitrile / -25 - 0 °C

3.1: 85 percent / DDQ; 4 Angstroem molecular sieves / CH₂Cl₂ / 5 h / 0 °C

With tin(II) trifluoromethanesulfonate; 4 A molecular sieve; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tetramethylammonium triacetoxyborohydride; In dichloromethane; acetonitrile;
DOI:10.1021/ja020091v