182193-69-7

Basic information

• Product Name: 3-Pentanone, 1-[(4-methoxyphenyl)methoxy]-2-methyl-, (2S)-
• CAS NO: 182193-69-7
• Molecular Formula: C14H20O3
• Molecular Weight: 236.311
• Mol File: 182193-69-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-Pentanone, 1-[(4-methoxyphenyl)methoxy]-2-methyl-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pentanone, 1-[(4-methoxyphenyl)methoxy]-2-methyl-, (2S)-(182193-69-7)
• EPA Substance Registry System: 3-Pentanone, 1-[(4-methoxyphenyl)methoxy]-2-methyl-, (2S)-(182193-69-7)

Safety Data

• Hazardous Substances Data: 182193-69-7(Hazardous Substances Data)

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 2386-64-3 ethylmagnesium chloride 
• 185203-71-8 methyl (S)-N-methyl-N-methoxy-3-(4-methoxybenzyloxy)-2-methylpropanoate 
• 132969-60-9 (2S)-3-[(4-methoxybenzyl)oxy]-2-methylpropanal 
• 132969-71-2 methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate 
• 925-90-6 ethylmagnesium bromide 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 

Downstream Products

• 548437-25-8 (2S,4S,5S,6S)-5-hydroxy-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptan-3-one 
• 496035-35-9 (2S,4S)-1-hydroxy-5-(p-methoxybenzyloxy)-2,4-dimethylpentan-3-one 
• 1184762-47-7 (2S,4S,5R,6S)-6-(tert-butyldimethylsilanyloxymethyl)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6,10-tetramethylundec-9-en-3-one 
• 1186618-97-2 C₂₄H₄₂O₅Si 
• 1186619-08-8 C₃₄H₄₆O₅Si 
• 449174-27-0 (2S,4R,5S,6R,7R)-7-(benzyloxy-diisopropyl-silanyloxy)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyl-nonan-3-one 
• 449174-12-3 (2S,4R,5S,6R,7S)-7-(benzyloxy-diisopropyl-silanyloxy)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyl-nonan-3-one 
• 827017-68-5 (2S,3R,4S,5S)-1-(4-methoxybenzyloxy)-7-(benzyloxy)-2,4-dimethylheptane-3,5-diol 
• 827603-03-2 (2S,4S,5R)-6-(tert-butyldimethylsilyloxy)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4-dimethylhexan-3-one 

Relevant articles and documents

Total synthesis of phorboxazole A via de novo oxazole formation: Strategy and component assembly

The phorboxazole natural products are among the most potent inhibitors of cancer cell division, but they are essentially unavailable from natural sources at present. Laboratory syntheses based upon tri-component fragment coupling strategies have been developed that provide phorboxazole A and analogues in a reliable manner and with unprecedented efficiency. This has been orchestrated to occur via the sequential or simultaneous formation of both of the natural product's oxazole moieties from two serine-derived amides, involving oxidation-cyclodehydrations. The optimized preparation of three pre-assembled components, representing carbons 3-17, 18-30, and 31-46, has been developed. This article details the design and syntheses of these three essential building blocks. The convergent coupling approach is designed to facilitate the incorporation of structural changes within each component to generate unnatural analogues, targeting those with enhanced therapeutic potential and efficacy.

SYNTHESIS OF DISCODERMOLIDE

The invention relates to a process for preparing discodermolide, for preparing intermediates for the manufacture of discodermolide and discodermolide analogues and to the intermediates obtained during the process. Wherein the process proceeds via a tetrae

Toward the combinatorial synthesis of polyketide libraries: Asymmetric aldol reactions with α-chiral aldehydes on solid support

(Matrix presented) The viability of performing stereocontrolled aldol additions with α-chiral aldehydes attached by a silyl linker to a hydroxymethylpolystyrene resin is demonstrated for boron and titanium enolates. Subsequent ketone reduction and manipul