(1S,7aS)-1-(tert-Butyl-diphenyl-silanyloxy)-3-isopropylidene-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one

Base Information

Chemical Name:(1S,7aS)-1-(tert-Butyl-diphenyl-silanyloxy)-3-isopropylidene-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one
CAS No.:158523-36-5
Molecular Formula:C₂₉H₃₆O₂Si
Molecular Weight:444.689
Hs Code.:

Synonyms:(1S,7aS)-1-(tert-Butyl-diphenyl-silanyloxy)-3-isopropylidene-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one

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Chemical Property of (1S,7aS)-1-(tert-Butyl-diphenyl-silanyloxy)-3-isopropylidene-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one

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Technology Process of (1S,7aS)-1-(tert-Butyl-diphenyl-silanyloxy)-3-isopropylidene-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one

There total 4 articles about (1S,7aS)-1-(tert-Butyl-diphenyl-silanyloxy)-3-isopropylidene-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 158523-35-4
C₃₁H₄₂O₄Si

: 158523-36-5
(1S,7aS)-1-(tert-Butyl-diphenyl-silanyloxy)-3-isopropylidene-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one

Guidance literature:: With pyridinium p-toluenesulfonate; In water; acetone; for 18h; Heating;
DOI:10.1080/00397919408010213

Reference yield:

: 126541-54-6
(1(S),7a(S))-1-(tert-butyldiphenylsiloxy)-7a-methyl-7,7a-dihydro-5(6H)-indanone

: 158523-36-5
(1S,7aS)-1-(tert-Butyl-diphenyl-silanyloxy)-3-isopropylidene-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / NBS, benzoyl peroxide / CCl₄ / 1.5 h / Heating

2: 77 percent / p-toluenesulfonic acid / benzene / 7 h / Heating

3: 1.) α,α'-bipyridyl, t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 3 h

4: 83 percent / PPTS / acetone; H₂O / 18 h / Heating

With [2,2]bipyridinyl; N-Bromosuccinimide; Perbenzoic acid; tert.-butyl lithium; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; In tetrachloromethane; water; acetone; benzene;
DOI:10.1080/00397919408010213

Reference yield:

: (1(S),7a(S))-(tert-butyldiphenylsiloxy)-3-bromo-7a-methyl-7,7a-dihydro-5(6H)-indanone

: 158523-36-5
(1S,7aS)-1-(tert-Butyl-diphenyl-silanyloxy)-3-isopropylidene-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / p-toluenesulfonic acid / benzene / 7 h / Heating

2: 1.) α,α'-bipyridyl, t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 3 h

3: 83 percent / PPTS / acetone; H₂O / 18 h / Heating

With [2,2]bipyridinyl; tert.-butyl lithium; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; In water; acetone; benzene;
DOI:10.1080/00397919408010213