(1(S),7a(S))-1-(tert-butyldiphenylsiloxy)-7a-methyl-7,7a-dihydro-5(6H)-indanone

Base Information

Chemical Name:(1(S),7a(S))-1-(tert-butyldiphenylsiloxy)-7a-methyl-7,7a-dihydro-5(6H)-indanone
CAS No.:126541-54-6
Molecular Formula:C₂₆H₃₂O₂Si
Molecular Weight:404.624
Hs Code.:

Synonyms:(1(S),7a(S))-1-(tert-butyldiphenylsiloxy)-7a-methyl-7,7a-dihydro-5(6H)-indanone

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Chemical Property of (1(S),7a(S))-1-(tert-butyldiphenylsiloxy)-7a-methyl-7,7a-dihydro-5(6H)-indanone

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Technology Process of (1(S),7a(S))-1-(tert-butyldiphenylsiloxy)-7a-methyl-7,7a-dihydro-5(6H)-indanone

There total 1 articles about (1(S),7a(S))-1-(tert-butyldiphenylsiloxy)-7a-methyl-7,7a-dihydro-5(6H)-indanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 16271-49-1
(1S,7aS)-1-hydroxy-7a-methyl-2,3,7,7a-tetrahydro-1H-inden-5(6H)-one

: 58479-61-1
tert-butylchlorodiphenylsilane

: 126541-54-6
(1(S),7a(S))-1-(tert-butyldiphenylsiloxy)-7a-methyl-7,7a-dihydro-5(6H)-indanone

Guidance literature:: With 1H-imidazole; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1021/jo00022a018

Reference yield: 14.0%

: 126541-54-6
(1(S),7a(S))-1-(tert-butyldiphenylsiloxy)-7a-methyl-7,7a-dihydro-5(6H)-indanone

: (1(S),7a(S))-(tert-butyldiphenylsiloxy)-3-bromo-7a-methyl-7,7a-dihydro-5(6H)-indanone

: (1S,7aS)-3,4-Dibromo-1-(tert-butyl-diphenyl-silanyloxy)-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one

Guidance literature:: With N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; for 1.5h; Heating;
DOI:10.1080/00397919408010213

Reference yield:

: 126541-54-6
(1(S),7a(S))-1-(tert-butyldiphenylsiloxy)-7a-methyl-7,7a-dihydro-5(6H)-indanone

: (1(S),3(R),7a(S))-1-(tert-butyldiphenylsioxy)-3β-isopropyl-7a-methyl-7,7a-dihydro-5(6H)-indanone

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / NBS, benzoyl peroxide / CCl₄ / 1.5 h / Heating

2: 77 percent / p-toluenesulfonic acid / benzene / 7 h / Heating

3: 1.) α,α'-bipyridyl, t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 3 h

4: 83 percent / PPTS / acetone; H₂O / 18 h / Heating

5: 98 percent / cyclohexene / 10percent Pd/C / ethanol / 12 h / Heating

With [2,2]bipyridinyl; N-Bromosuccinimide; Perbenzoic acid; tert.-butyl lithium; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; cyclohexene; palladium on activated charcoal; In tetrachloromethane; ethanol; water; acetone; benzene;
DOI:10.1080/00397919408010213