5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethyleneadenosine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethyleneadenosine
• CAS No.: 73793-98-3
• Molecular Formula: C₃₄H₃₆N₆O₆
• Molecular Weight: 624.696
• Mol file: 73793-98-3.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethyleneadenosine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethyleneadenosine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethyleneadenosine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethyleneadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N6-(N,N'-Dimethylaminomethylene)adenosine (17331-15-6) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-O-(4,4'-dimethoxytrityl)-N6-dimethylaminomethyleneadenosine (73793-98-3)

Guidance literature:

In pyridine; N,N-dimethyl-formamide; for 10h; Ambient temperature;

DOI:10.1055/s-1989-27258

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-O-(4,4'-dimethoxytrityl)-N6-dimethylaminomethyleneadenosine (73793-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 4 h / Ambient temperature

2: methanol

With methanol; In pyridine;

DOI:10.1016/S0040-4039(97)01767-X

Reference yield:

N'-[9-((3aR,4R,6R,6aR)-2-Dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-N,N-dimethyl-formamidine (17331-18-9) → 5'-O-(4,4'-dimethoxytrityl)-N6-dimethylaminomethyleneadenosine (73793-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 4 h / Ambient temperature

2: methanol

With methanol; In pyridine;

DOI:10.1016/S0040-4039(97)01767-X

upstream raw materials:

N⁶-(N,N'-Dimethylaminomethylene)adenosine

4,4'-dimethoxytrityl chloride

N'-[9-((3aR,4R,6R,6aR)-2-Dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-N,N-dimethyl-formamidine

adenosine

Downstream raw materials:

Thiophosphoric acid O-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl] ester

adenosine monophosphate

adenosine 2',3'-cyclic monophosphate

adenosine