3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione

Base Information

• Chemical Name: 3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione
• CAS No.: 108564-92-7
• Molecular Formula: C₁₂H₁₀N₄O₂
• Molecular Weight: 242.237
• Mol file: 108564-92-7.mol

Synonyms:3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione

Chemical Property of 3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione

There total 6 articles about 3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-amino-3-(cyanomethyl)-1-phenyl-1H-pyrazole-4-carbonitrile (7152-40-1) → 3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione (108564-92-7)

Guidance literature:

With hydrogenchloride; water; at 70 ℃;

Reference yield: 54.0%

2-(5-amino-4-carbamoyl-1-phenyl-1H-pyrazol-3-yl)acetic acid (100517-95-1) → 3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione (108564-92-7)

Guidance literature:

With acetic anhydride; for 3h; Heating;

DOI:10.1016/j.tet.2007.07.034

Reference yield:

1,1,3-tricyano-2-amino-1-propene (868-54-2) → 3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione (108564-92-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 41 percent / ethanol / 0.25 h / Heating

2: 77 percent / NaOH; water / 0.83 h / Heating

3: 54 percent / acetic anhydride / 3 h / Heating

With sodium hydroxide; water; acetic anhydride; In ethanol;

DOI:10.1016/j.tet.2007.07.034

upstream raw materials:

5-amino-3-(cyanomethyl)-1-phenyl-1H-pyrazole-4-carbonitrile

2-(5-amino-4-carbamoyl-1-phenyl-1H-pyrazol-3-yl)acetic acid

1,1,3-tricyano-2-amino-1-propene

phenylhydrazine

Downstream raw materials:

N-(4,6-dioxo-2-phenyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]-pyridine-3-yl)acetamide

C₁₅H₁₆N₄O₂

3-amino-7,7-dimethyl-2-phenyl-2,7-dihydro-pyrazolo[4,3-c]pyridine-4,6-dione

C₁₅H₁₄N₄O₂