2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino}-1-cyclohexylethanol

Base Information

Chemical Name:2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino}-1-cyclohexylethanol
CAS No.:1414772-44-3
Molecular Formula:C₂₂H₂₄N₄O₂
Molecular Weight:376.458
Hs Code.:

Synonyms:2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino}-1-cyclohexylethanol

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Chemical Property of 2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino}-1-cyclohexylethanol

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Technology Process of 2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino}-1-cyclohexylethanol

There total 3 articles about 2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino}-1-cyclohexylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 57230-08-7
1-amino-2-cyclohexylethan-2-ol

: 1414772-61-4
3-(1-benzofuran-2-yl)-6-chloroimidazo[1,2-b]pyridazine

: 1414772-44-3
2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino}-1-cyclohexylethanol

Guidance literature:: In butan-1-ol; at 150 ℃; for 25h;

Reference yield:

: 13526-66-4
3-bromo-6-chloro-imidazo[1,2-b]pyridazine

: 1414772-44-3
2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino}-1-cyclohexylethanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 24 h / 100 °C

2: butan-1-ol / 25 h / 150 °C

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; butan-1-ol;

Reference yield:

: 98437-24-2
benzofuran-2-boronic acid

: 1414772-44-3
2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino}-1-cyclohexylethanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 24 h / 100 °C

2: butan-1-ol / 25 h / 150 °C

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; butan-1-ol;