6-(2-{4-[3-(4-chlorophenoxy)propionyl]piperazin-1-yl}acetyl)-3H-benzoxazol-2-one

Base Information

Chemical Name:6-(2-{4-[3-(4-chlorophenoxy)propionyl]piperazin-1-yl}acetyl)-3H-benzoxazol-2-one
CAS No.:1144036-94-1
Molecular Formula:C₂₂H₂₂ClN₃O₅
Molecular Weight:443.887
Hs Code.:

Synonyms:6-(2-{4-[3-(4-chlorophenoxy)propionyl]piperazin-1-yl}acetyl)-3H-benzoxazol-2-one

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Chemical Property of 6-(2-{4-[3-(4-chlorophenoxy)propionyl]piperazin-1-yl}acetyl)-3H-benzoxazol-2-one

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Technology Process of 6-(2-{4-[3-(4-chlorophenoxy)propionyl]piperazin-1-yl}acetyl)-3H-benzoxazol-2-one

There total 4 articles about 6-(2-{4-[3-(4-chlorophenoxy)propionyl]piperazin-1-yl}acetyl)-3H-benzoxazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

: 1177209-04-9
C₁₃H₁₇ClN₂O₂

: 54903-10-5
6-(2-chloroacetyl)-2,3-dihydro-1,3-benzoxazol-2-one

: 1144036-94-1
6-(2-{4-[3-(4-chlorophenoxy)propionyl]piperazin-1-yl}acetyl)-3H-benzoxazol-2-one

Guidance literature:: With triethylamine; In acetonitrile; at 20 - 80 ℃; for 32h;

Reference yield:

: 3284-79-5
3-(4-chlorophenoxy)propionic acid

: 1144036-94-1
6-(2-{4-[3-(4-chlorophenoxy)propionyl]piperazin-1-yl}acetyl)-3H-benzoxazol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 16 h / 20 °C

2: hydrogenchloride; propan-1-ol / 0.5 h / 20 °C

3: triethylamine / acetonitrile / 32 h / 20 - 80 °C

With 4-methyl-morpholine; hydrogenchloride; propan-1-ol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1246640-00-5
C₁₈H₂₅ClN₂O₄

: 1144036-94-1
6-(2-{4-[3-(4-chlorophenoxy)propionyl]piperazin-1-yl}acetyl)-3H-benzoxazol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; propan-1-ol / 0.5 h / 20 °C

2: triethylamine / acetonitrile / 32 h / 20 - 80 °C

With hydrogenchloride; propan-1-ol; triethylamine; In acetonitrile;