2-fluoro-N-(2-iodo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-3-nitrobenzamide

Base Information

• Chemical Name: 2-fluoro-N-(2-iodo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-3-nitrobenzamide
• CAS No.: 1207316-03-7
• Molecular Formula: C₁₇H₆F₁₁IN₂O₃
• Molecular Weight: 622.133
• Mol file: 1207316-03-7.mol

Synonyms:2-fluoro-N-(2-iodo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-3-nitrobenzamide

Chemical Property of 2-fluoro-N-(2-iodo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-3-nitrobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-N-(2-iodo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-3-nitrobenzamide

There total 5 articles about 2-fluoro-N-(2-iodo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-3-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.8%

2-fluoro-3-nitro-benzoyl chloride (1214341-16-8) + 2-iodo-4-(perfluoropropan-2-yl)-6-(trifluoromethoxy)aniline → 2-fluoro-N-(2-iodo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-3-nitrobenzamide (1207316-03-7)

Guidance literature:

With 1,3-dimethyl-2-imidazolidinone; N-ethyl-N,N-diisopropylamine; at 105 ℃; for 5h; Large scale;

Reference yield:

2-(trifluoromethyl)benzenamine (88-17-5) → 2-fluoro-N-(2-iodo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-3-nitrobenzamide (1207316-03-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutylammomium bromide; sodium dithionite; sodium carbonate / water; ethyl acetate / 6 h / 30 °C / pH 4.4

2: sulfuric acid; iodine; ammonium persulfate / water; methanol / 5.5 h / 60 °C

3: 1,3-dimethyl-2-imidazolidinone; N-ethyl-N,N-diisopropylamine / 5 h / 105 °C / Large scale

With 1,3-dimethyl-2-imidazolidinone; ammonium persulfate; sodium dithionite; sulfuric acid; tetrabutylammomium bromide; iodine; sodium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; water; ethyl acetate;

Reference yield:

4-(perfluoropropane-2-yl)-2-(trifluoromethyl)aniline (1207314-85-9) → 2-fluoro-N-(2-iodo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-3-nitrobenzamide (1207316-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; iodine; ammonium persulfate / water; methanol / 5.5 h / 60 °C

2: 1,3-dimethyl-2-imidazolidinone; N-ethyl-N,N-diisopropylamine / 5 h / 105 °C / Large scale

With 1,3-dimethyl-2-imidazolidinone; ammonium persulfate; sulfuric acid; iodine; N-ethyl-N,N-diisopropylamine; In methanol; water;

upstream raw materials:

2-(trifluoromethyl)benzenamine

4-(perfluoropropane-2-yl)-2-(trifluoromethyl)aniline

2-fluoro-3-nitro-benzoyl chloride

2-fluoro-3-nitro-benzoic acid

Downstream raw materials:

3-amino-2-fluoro-N-[2-iodo-4-[1,1,1,2,3,3-heptafluoroprop-2-yl]-6-(trifluoromethyl)phenyl]benzamide