2-Fluoro-3-nitrobenzoyl chloride

Base Information

• Chemical Name: 2-Fluoro-3-nitrobenzoyl chloride
• CAS No.: 1214341-16-8
• Molecular Formula: C₇H₃ClFNO₃
• Molecular Weight: 203.557
• Mol file: 1214341-16-8.mol

Synonyms:2-fluoro-3-nitro-benzoyl chloride

Chemical Property of 2-Fluoro-3-nitrobenzoyl chloride

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

2-Fluoro-3-nitrobenzoylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Fluoro-3-nitrobenzoyl chloride

There total 2 articles about 2-Fluoro-3-nitrobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-fluoro-3-nitro-benzoic acid (317-46-4) → 2-fluoro-3-nitro-benzoyl chloride (1214341-16-8)

Guidance literature:

With thionyl chloride; at 80 ℃; for 5h;

DOI:10.3390/molecules25061451

Reference yield:

2-fluoro-3-nitrobenzaldehyde (96516-29-9) → 2-fluoro-3-nitro-benzoyl chloride (1214341-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: water; aminosulfonic acid; sodium chlorite / 1,4-dioxane / 0.5 h / 20 °C

2: thionyl chloride / N,N-dimethyl-formamide / 80 °C

With sodium chlorite; thionyl chloride; aminosulfonic acid; water; N,N-dimethyl-formamide; In 1,4-dioxane;

Reference yield: 100.0%

2-fluoro-3-nitro-benzoyl chloride (1214341-16-8) + 2-bromo-4-[1-[bromo(difluoro)methyl]-1,2,2,2-tetrafluoro-ethyl]-6-chloro-aniline → N-[2-bromo-4-[1-[bromo(difluoro)methyl]-1,2,2,2-tetrafluoro-ethyl]-6-chloro-phenyl]-2-fluoro-3-nitro-benzamide

Guidance literature:

With potassium iodide; In acetonitrile; at 82 ℃;

upstream raw materials:

2-fluoro-3-nitro-benzoic acid

2-fluoro-3-nitrobenzaldehyde

Downstream raw materials:

N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-fluoro-3-nitrobenzamide

(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone

(3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone

N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide