2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole

Base Information

• Chemical Name: 2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole
• CAS No.: 748764-57-0
• Molecular Formula: C₁₇H₁₄BrN₃OS
• Molecular Weight: 388.288
• Mol file: 748764-57-0.mol

Synonyms:2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole

Chemical Property of 2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole

There total 3 articles about 2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-bromobenzylidene)hydrazine carbothioamide (36449-43-1) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole (748764-57-0)

Guidance literature:

With sodium acetate; acetic acid; In ethanol; at 20 ℃;

DOI:10.13005/ojc/340360

Reference yield:

2-phenoxy-4-(4-methoxyphenyl)thiazole (1629144-43-9) → 2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole (748764-57-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere; Schlenk technique

2: acetic acid / ethanol; methanol / 1 h / 80 °C / Inert atmosphere; Schlenk technique

With acetic acid; hydrazine; In methanol; ethanol; dimethyl sulfoxide;

DOI:10.1002/ejoc.201402129

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → 2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole (748764-57-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aminosulfonic acid / ethanol / 20 °C

2: sodium acetate; acetic acid / ethanol / 20 °C

With aminosulfonic acid; sodium acetate; acetic acid; In ethanol;

DOI:10.13005/ojc/340360

upstream raw materials:

2-phenoxy-4-(4-methoxyphenyl)thiazole

4-bromo-benzaldehyde

2-(4-bromobenzylidene)hydrazine carbothioamide

2-Bromo-4'-methoxyacetophenone