(R)-4-{7-[3-methoxy-4-(tetrahydro-pyran-4-yloxy)phenyl]-[1,6]naphthyridine-5-yloxymethyl}pyrrolidine-2-one

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Chemical Name:(R)-4-{7-[3-methoxy-4-(tetrahydro-pyran-4-yloxy)phenyl]-[1,6]naphthyridine-5-yloxymethyl}pyrrolidine-2-one
CAS No.:1319738-03-8
Molecular Formula:C₂₅H₂₇N₃O₅
Molecular Weight:449.506
Hs Code.:

Synonyms:(R)-4-{7-[3-methoxy-4-(tetrahydro-pyran-4-yloxy)phenyl]-[1,6]naphthyridine-5-yloxymethyl}pyrrolidine-2-one

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Chemical Property of (R)-4-{7-[3-methoxy-4-(tetrahydro-pyran-4-yloxy)phenyl]-[1,6]naphthyridine-5-yloxymethyl}pyrrolidine-2-one

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Technology Process of (R)-4-{7-[3-methoxy-4-(tetrahydro-pyran-4-yloxy)phenyl]-[1,6]naphthyridine-5-yloxymethyl}pyrrolidine-2-one

There total 3 articles about (R)-4-{7-[3-methoxy-4-(tetrahydro-pyran-4-yloxy)phenyl]-[1,6]naphthyridine-5-yloxymethyl}pyrrolidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1165450-70-3
(R)-4-(hydroxymethyl)pyrrolidine-2-one

: 1319737-67-1
5-chloro-7-[3-methoxy-4-(tetrahydro-pyran-4-yloxy)-phenyl]-[1,6]naphthyridine

: 1319738-03-8
(R)-4-{7-[3-methoxy-4-(tetrahydro-pyran-4-yloxy)phenyl]-[1,6]naphthyridine-5-yloxymethyl}pyrrolidine-2-one

Guidance literature:: In N,N-dimethyl acetamide; at 20 - 70 ℃; Inert atmosphere;

Reference yield:

: 99735-43-0,96449-93-3,99735-44-1
(3R)-1-((R)-1-phenylethyl)-5-oxo-3-pyrrolidinecarboxylic acid

: 1319738-03-8
(R)-4-{7-[3-methoxy-4-(tetrahydro-pyran-4-yloxy)phenyl]-[1,6]naphthyridine-5-yloxymethyl}pyrrolidine-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 2.5 h / 0 - 25 °C

2: trifluoroacetic acid / 2 h / 150 °C / Microwave irradiation

3: N,N-dimethyl acetamide / 20 - 70 °C / Inert atmosphere

With dimethylsulfide borane complex; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 190957-22-3
(4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one

: 1319738-03-8
(R)-4-{7-[3-methoxy-4-(tetrahydro-pyran-4-yloxy)phenyl]-[1,6]naphthyridine-5-yloxymethyl}pyrrolidine-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 2 h / 150 °C / Microwave irradiation

2: N,N-dimethyl acetamide / 20 - 70 °C / Inert atmosphere

With trifluoroacetic acid; In N,N-dimethyl acetamide;