1165450-70-3

Basic information

• Product Name: (4R)-4-(hydroxyMethyl)-2-Pyrrolidinone
• Synonyms: (4R)-4-(hydroxyMethyl)-2-Pyrrolidinone;(R)-4-(hydroxymethyl)pyrrolidin-2-one
• CAS NO: 1165450-70-3
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.13046
• Mol File: 1165450-70-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 346.0±15.0 °C(Predicted)
• Appearance: /
• Density: 1.153±0.06 g/cm3(Predicted)
• PKA: 14.56±0.10(Predicted)
• CAS DataBase Reference: (4R)-4-(hydroxyMethyl)-2-Pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-4-(hydroxyMethyl)-2-Pyrrolidinone(1165450-70-3)
• EPA Substance Registry System: (4R)-4-(hydroxyMethyl)-2-Pyrrolidinone(1165450-70-3)

Safety Data

• Hazardous Substances Data: 1165450-70-3(Hazardous Substances Data)

Usage

General Description

(4R)-4-(hydroxyMethyl)-2-Pyrrolidinone is a chemical compound that belongs to the class of pyrrolidinones. It is a colorless to pale yellow liquid with a faint odor, and it is soluble in water and most organic solvents. (4R)-4-(hydroxyMethyl)-2-Pyrrolidinone has various industrial uses, including as a solvent, a corrosion inhibitor, a reactive diluent in radiation-curable coatings, and a monomer in the production of polyvinylpyrrolidone (PVP). It is also used in the synthesis of pharmaceuticals and agrochemicals. Additionally, (4R)-4-(hydroxyMethyl)-2-Pyrrolidinone has potential applications in the production of polymers, resins, and adhesives. (4R)-4-(hydroxyMethyl)-2-Pyrrolidinone is considered to have low toxicity and is generally regarded as safe for use in specific applications, with proper handling and storage precautions.

Upstream product

• 192214-02-1 β-azidomethyl γ-butyrolactone 
• 190957-22-3 (4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one 
• 99735-43-0 (3R)-1-((R)-1-phenylethyl)-5-oxo-3-pyrrolidinecarboxylic acid 

Downstream Products

• 1319737-93-3 (R)-4-{7-[4-(tetrahydro-pyran-4-yloxy)-3-trifluoromethyl-phenyl]-[1,6]naphthyridine-5-yloxymethyl}pyrrolidine-2-one 
• 1319738-03-8 (R)-4-{7-[3-methoxy-4-(tetrahydro-pyran-4-yloxy)phenyl]-[1,6]naphthyridine-5-yloxymethyl}pyrrolidine-2-one 
• 1319738-12-9 (R)-4-[7-(3-Fluoro-4-isopropoxy-phenyl)-[1,6]naphthyridine-5-yloxy-methyl]-pyrrolidine-2-one 

Relevant articles and documents

3,4-Methano-β-proline: A conformationally constrained β-amino acid

An enantiomerically pure, conformationally constrained β-proline derivative, 3,4-methano-β-proline, was synthesized starting with a readily available bicyclic lactone by using a straightforward synthetic route.

SUBSTITUTED NAPHTHYRIDINES AND THEIR USE AS SYK KINASE INHIBITORS

The invention relates to new substituted naphthyridines of formula (1), as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among -O-R3 or -NR3R4, R3 is C1-6-alkyl which is substituted by R5 and R6 R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, -C1-6-alkylen-O-C1-3-alkyl, C1-3-haloalkyl, R6 is ring X wherein n is either 0 or 1, and Formula (I) is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, -C1-3-alkyl, -C1-3-haloalkyl, -O-C1-3-alkyl, -C1-3-alkanol and halogen, and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.