N-[3,5-bis(trifluoromethyl)benzyl]-2-(chloromethyl)-4-phenylnicotinamide

Base Information

Chemical Name:N-[3,5-bis(trifluoromethyl)benzyl]-2-(chloromethyl)-4-phenylnicotinamide
CAS No.:1303445-76-2
Molecular Formula:C₂₂H₁₅ClF₆N₂O
Molecular Weight:472.817
Hs Code.:

Synonyms:N-[3,5-bis(trifluoromethyl)benzyl]-2-(chloromethyl)-4-phenylnicotinamide

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Chemical Property of N-[3,5-bis(trifluoromethyl)benzyl]-2-(chloromethyl)-4-phenylnicotinamide

Chemical Property:

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Technology Process of N-[3,5-bis(trifluoromethyl)benzyl]-2-(chloromethyl)-4-phenylnicotinamide

There total 3 articles about N-[3,5-bis(trifluoromethyl)benzyl]-2-(chloromethyl)-4-phenylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1303445-70-6
N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-4-phenylnicotinamide 1-oxide

: 1303445-76-2
N-[3,5-bis(trifluoromethyl)benzyl]-2-(chloromethyl)-4-phenylnicotinamide

: 1303445-74-0
N-[3,5-bis(trifluoromethyl)benzyl]-6-chloro-2-methyl-4-phenylnicotinamide

Guidance literature:: With trichlorophosphate; for 3h; Reflux;
DOI:10.1016/j.bmc.2011.02.031

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 1303445-76-2
N-[3,5-bis(trifluoromethyl)benzyl]-2-(chloromethyl)-4-phenylnicotinamide

: 1303445-74-0
N-[3,5-bis(trifluoromethyl)benzyl]-6-chloro-2-methyl-4-phenylnicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: piperidine / N,N-dimethyl-formamide / 1 h / Reflux

2.1: sodium hydroxide / ethanol / 6 h / Reflux

2.2: 0 - 5 °C / pH 5 - 6

3.1: thionyl chloride / 3 h / Reflux

4.1: triethylamine / dichloromethane / 1 h / Reflux

5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 20 °C

6.1: trichlorophosphate / 3 h / Reflux

With piperidine; thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.02.031

Reference yield:

: 1256643-39-6
2-methyl-4-phenylnicotinic acid

: 1303445-76-2
N-[3,5-bis(trifluoromethyl)benzyl]-2-(chloromethyl)-4-phenylnicotinamide

: 1303445-74-0
N-[3,5-bis(trifluoromethyl)benzyl]-6-chloro-2-methyl-4-phenylnicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 3 h / Reflux

2: triethylamine / dichloromethane / 1 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 20 °C

4: trichlorophosphate / 3 h / Reflux

With thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; chloroform;
DOI:10.1016/j.bmc.2011.02.031