N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-4-phenylnicotinamide 1-oxide

Base Information

Chemical Name:N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-4-phenylnicotinamide 1-oxide
CAS No.:1303445-70-6
Molecular Formula:C₂₂H₁₆F₆N₂O₂
Molecular Weight:454.372
Hs Code.:

Synonyms:N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-4-phenylnicotinamide 1-oxide

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Chemical Property of N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-4-phenylnicotinamide 1-oxide

Chemical Property:

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Technology Process of N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-4-phenylnicotinamide 1-oxide

There total 4 articles about N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-4-phenylnicotinamide 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256643-39-6
2-methyl-4-phenylnicotinic acid

: 1303445-70-6
N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-4-phenylnicotinamide 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 3 h / Reflux

2: triethylamine / dichloromethane / 1 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 20 °C

With thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform;
DOI:10.1016/j.bmc.2011.02.031

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 1303445-70-6
N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-4-phenylnicotinamide 1-oxide

Guidance literature:: Multi-step reaction with 5 steps

1.1: piperidine / N,N-dimethyl-formamide / 1 h / Reflux

2.1: sodium hydroxide / ethanol / 6 h / Reflux

2.2: 0 - 5 °C / pH 5 - 6

3.1: thionyl chloride / 3 h / Reflux

4.1: triethylamine / dichloromethane / 1 h / Reflux

5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 20 °C

With piperidine; thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.02.031

Reference yield:

: C₁₃H₁₀ClNO

: 1303445-70-6
N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-4-phenylnicotinamide 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / Reflux

2: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 20 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform;
DOI:10.1016/j.bmc.2011.02.031