Technology Process of (R)-3-((2-aminophenyl)thio)-N,N-dimethyl-3-phenylpropanethioamide
There total 1 articles about (R)-3-((2-aminophenyl)thio)-N,N-dimethyl-3-phenylpropanethioamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; mesitylcopper(I);
In
toluene;
at 0 ℃;
for 6h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201204365
- Guidance literature:
-
(R)-3-((2-aminophenyl)thio)-N,N-dimethyl-3-phenylpropanethioamide;
With
trifluorormethanesulfonic acid; methyl iodide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 17h;
Inert atmosphere;
With
toluene-4-sulfonic acid;
In
toluene;
at 80 ℃;
for 2h;
Inert atmosphere;
DOI:10.1002/anie.201204365
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluorormethanesulfonic acid; methyl iodide / tetrahydrofuran; water / 17 h / 0 - 20 °C / Inert atmosphere
1.2: 2 h / 80 °C / Inert atmosphere
2.1: potassium carbonate / water; ethyl acetate / 18 h / Inert atmosphere; Reflux
3.1: hydrogenchloride / methanol / Inert atmosphere
With
hydrogenchloride; trifluorormethanesulfonic acid; potassium carbonate; methyl iodide;
In
tetrahydrofuran; methanol; water; ethyl acetate;
DOI:10.1002/anie.201204365
