3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole

Base Information

• Chemical Name: 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole
• CAS No.: 883013-26-1
• Molecular Formula: C₂₀H₂₀N₂O₃
• Molecular Weight: 336.39
• Mol file: 883013-26-1.mol

Synonyms:3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole

Chemical Property of 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole

There total 4 articles about 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

C13H18N2O3 (874485-04-8) + benzoic acid (65-85-0,8013-63-6) → 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole (883013-26-1)

Guidance literature:

benzoic acid; With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

C₁₃H₁₈N₂O₃; In N,N-dimethyl-formamide; at 0 - 110 ℃; for 13.5h; Inert atmosphere;

DOI:10.1111/j.1747-0285.2011.01304.x

Reference yield:

3-(cyclopentyloxy)-4-methoxybenzonitrile (159783-16-1) → 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole (883013-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 18 h / 0 °C / Reflux

2.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2.2: 13.5 h / 0 - 110 °C / Inert atmosphere

With hydroxylamine hydrochloride; dicyclohexyl-carbodiimide; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1111/j.1747-0285.2011.01304.x

Reference yield:

isovanillin (621-59-0) → 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole (883013-26-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: formic acid; hydroxylamine hydrochloride; sodium formate / 3 h / 125 °C

2.1: potassium carbonate / N,N-dimethyl-formamide

3.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 18 h / 0 °C / Reflux

4.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

4.2: 13.5 h / 0 - 110 °C / Inert atmosphere

With formic acid; hydroxylamine hydrochloride; sodium formate; potassium carbonate; dicyclohexyl-carbodiimide; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1111/j.1747-0285.2011.01304.x

upstream raw materials:

C₁₃H₁₈N₂O₃

benzoic acid

isovanillin

3-(cyclopentyloxy)-4-methoxybenzonitrile