2-(benzoyloxy)-1-[(2,2-dimethylpropanoyl)oxy]-2-oxoethyl 2-benzoyl-2-tert-butyl-1-(4-chlorobenzoyl)hydrazinecarboxylate

Base Information

• Chemical Name: 2-(benzoyloxy)-1-[(2,2-dimethylpropanoyl)oxy]-2-oxoethyl 2-benzoyl-2-tert-butyl-1-(4-chlorobenzoyl)hydrazinecarboxylate
• CAS No.: 352322-05-5
• Molecular Formula: C₃₃H₃₅ClN₂O₈
• Molecular Weight: 623.102
• Mol file: 352322-05-5.mol

Synonyms:2-(benzoyloxy)-1-[(2,2-dimethylpropanoyl)oxy]-2-oxoethyl 2-benzoyl-2-tert-butyl-1-(4-chlorobenzoyl)hydrazinecarboxylate

Chemical Property of 2-(benzoyloxy)-1-[(2,2-dimethylpropanoyl)oxy]-2-oxoethyl 2-benzoyl-2-tert-butyl-1-(4-chlorobenzoyl)hydrazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzoyloxy)-1-[(2,2-dimethylpropanoyl)oxy]-2-oxoethyl 2-benzoyl-2-tert-butyl-1-(4-chlorobenzoyl)hydrazinecarboxylate

There total 4 articles about 2-(benzoyloxy)-1-[(2,2-dimethylpropanoyl)oxy]-2-oxoethyl 2-benzoyl-2-tert-butyl-1-(4-chlorobenzoyl)hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

[N'-benzoyl-N'-tert-butyl-N-(4-chloro-benzoyl)-hydrazinocarbonyloxy]-iodo-acetic acid benzyl ester (352321-51-8) + Trimethylacetic acid (75-98-9) → 2-(benzoyloxy)-1-[(2,2-dimethylpropanoyl)oxy]-2-oxoethyl 2-benzoyl-2-tert-butyl-1-(4-chlorobenzoyl)hydrazinecarboxylate (352322-05-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1055/s-2002-20036

Reference yield:

benzylglyoxylate (52709-42-9) → 2-(benzoyloxy)-1-[(2,2-dimethylpropanoyl)oxy]-2-oxoethyl 2-benzoyl-2-tert-butyl-1-(4-chlorobenzoyl)hydrazinecarboxylate (352322-05-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 90 percent / pyridine / tetrahydrofuran / -65 - 60 °C

2.1: KO-t-Bu / tetrahydrofuran / 0.5 h / Heating

2.2: 75 percent / tetrahydrofuran / 2 h / 20 °C

3.1: 90 percent / NaI / acetone / 2 h / 30 °C

4.1: 80 percent / DIEA / tetrahydrofuran / 16 h / 20 °C

With pyridine; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; acetone; 3.1: Finkelstein reaction;

DOI:10.1055/s-2002-20036

Reference yield:

benzyl chloro[(chlorocarbonyl)oxy]acetate (352320-85-5) → 2-(benzoyloxy)-1-[(2,2-dimethylpropanoyl)oxy]-2-oxoethyl 2-benzoyl-2-tert-butyl-1-(4-chlorobenzoyl)hydrazinecarboxylate (352322-05-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: KO-t-Bu / tetrahydrofuran / 0.5 h / Heating

1.2: 75 percent / tetrahydrofuran / 2 h / 20 °C

2.1: 90 percent / NaI / acetone / 2 h / 30 °C

3.1: 80 percent / DIEA / tetrahydrofuran / 16 h / 20 °C

With potassium tert-butylate; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; acetone; 2.1: Finkelstein reaction;

DOI:10.1055/s-2002-20036

upstream raw materials:

[N'-benzoyl-N'-tert-butyl-N-(4-chloro-benzoyl)-hydrazinocarbonyloxy]-iodo-acetic acid benzyl ester

Trimethylacetic acid

benzylglyoxylate

benzyl chloro[(chlorocarbonyl)oxy]acetate

Downstream raw materials:

2,2-dimethyl-propionic acid [N'-benzoyl-N'-tert-butyl-N-(4-chloro-benzoyl)-hydrazinocarbonyloxy]-carboxy-methyl ester