(E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-[5-fluoro-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:(E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-[5-fluoro-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester
CAS No.:129141-75-9
Molecular Formula:C₂₆H₂₅FN₂O₈
Molecular Weight:512.492
Hs Code.:

(E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-[5-fluoro-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

Synonyms:(E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-[5-fluoro-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of (E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-[5-fluoro-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

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Technology Process of (E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-[5-fluoro-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

There total 8 articles about (E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-[5-fluoro-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 129141-72-6
(E)-3-Phenyl-acrylic acid (3aR,4R,6R,6aR)-6-[5-fluoro-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

: 129141-75-9
(E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-[5-fluoro-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With trifluoroacetic acid; In methanol; for 0.166667h; Ambient temperature;
DOI:10.1246/cl.1990.339

Reference yield:

: 2797-17-3
2',3'-O-isopropylidene-5-fluorouridine

: 129141-75-9
5'-O-cinnamoyl-3-(4-methoxybenzyl)-5-fluorouridine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / Ambient temperature

2: N,N-diisopropylethylamine / acetonitrile / 4 h / Ambient temperature

3: 80 percent methanolic trifluoroacetic acid / 0.17 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In acetonitrile;
DOI:10.1246/bcsj.64.2266

Reference yield:

: 129141-66-8
2',3'-O-Isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine

: 129141-75-9
5'-O-cinnamoyl-3-(4-methoxybenzyl)-5-fluorouridine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-diisopropylethylamine / acetonitrile / 4 h / Ambient temperature

2: 80 percent methanolic trifluoroacetic acid / 0.17 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In acetonitrile;
DOI:10.1246/bcsj.64.2266