2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime

Base Information

Chemical Name:2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime
CAS No.:1083067-06-4
Molecular Formula:C₁₉H₂₄FN₅O
Molecular Weight:357.431
Hs Code.:

Synonyms:2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime

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Chemical Property of 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime

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Technology Process of 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime

There total 5 articles about 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1083066-89-0
2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 1083067-06-4
2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime

Guidance literature:: 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h; Inert atmosphere;

(2-chloroethyl)dimethylamine hydrochloride; With triethylamine; In N,N-dimethyl-formamide; mineral oil; at 80 ℃;

Reference yield:

: 1083067-13-3
2-acetyl-5-(4-fluorophenyl)cyclohexane-1,3-dione

: 1083067-06-4
2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloroform / 20 °C

2.1: 1,4-dioxane / 16 h / 100 °C

3.1: hydroxylamine hydrochloride / pyridine / 1 h / 100 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C / Inert atmosphere

4.2: 80 °C

With hydroxylamine hydrochloride; sodium hydride; In 1,4-dioxane; pyridine; chloroform; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 945298-72-6
2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one

: 1083067-06-4
2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride / pyridine / 1 h / 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C / Inert atmosphere

2.2: 80 °C

With hydroxylamine hydrochloride; sodium hydride; In pyridine; N,N-dimethyl-formamide; mineral oil;