2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

Base Information

• Chemical Name: 2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine
• CAS No.: 256219-17-7
• Molecular Formula: C₁₈H₁₅F₂N₃O₃S
• Molecular Weight: 391.398
• Mol file: 256219-17-7.mol

Synonyms:2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

Chemical Property of 2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

There total 3 articles about 2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

thiophosgene (463-71-8) + 2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-nitrophenyl)-1,4-dihydropyridine (256219-12-2) → 2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine (256219-17-7)

Guidance literature:

thiophosgene; 2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-nitrophenyl)-1,4-dihydropyridine; In dichloromethane; at 20 ℃;

With aluminum oxide; In toluene; Heating;

DOI:10.1021/jm990443h

Reference yield:

o-difluoromethoxybenzaldehyde (71653-64-0) → 2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine (256219-17-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 90 percent / H₂SO₄; fumic nitric acid / 1 h / 20 °C

2.1: 57 percent / acetic acid / 2 h / Heating

3.1: CH₂Cl₂ / 20 °C

3.2: 51 percent / Al₂O₃ / toluene / Heating

With sulfuric acid; nitric acid; acetic acid; In dichloromethane; 1.1: Nitration / 2.1: Cyclization / 3.1: thiophosgenation / 3.2: thiophosgenation;

DOI:10.1021/jm990443h

Reference yield:

o-difluoromethoxy-5-nitrobenzaldehyde (145742-63-8) → 2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine (256219-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 57 percent / acetic acid / 2 h / Heating

2.1: CH₂Cl₂ / 20 °C

2.2: 51 percent / Al₂O₃ / toluene / Heating

With acetic acid; In dichloromethane; 1.1: Cyclization / 2.1: thiophosgenation / 2.2: thiophosgenation;

DOI:10.1021/jm990443h

upstream raw materials:

thiophosgene

2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-nitrophenyl)-1,4-dihydropyridine

o-difluoromethoxybenzaldehyde

o-difluoromethoxy-5-nitrobenzaldehyde

Downstream raw materials:

2,6-dimethyl-3-carbomethoxy-5-cyano-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine

5-cyano-4-[2-difluoromethoxy-5-(1,2,2-trimethyl-propyliminomethyleneamino)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylic acid methyl ester