(1'R,2'S)-(2'-Dimethylamino-1'-phenylpropyl) (4E)-3-(tert-butyldimethylsiloxy)-2,4-dimethylhex-4-enoate

Base Information

Chemical Name:(1'R,2'S)-(2'-Dimethylamino-1'-phenylpropyl) (4E)-3-(tert-butyldimethylsiloxy)-2,4-dimethylhex-4-enoate
CAS No.:138133-37-6
Molecular Formula:C₂₅H₄₃NO₃Si
Molecular Weight:433.707
Hs Code.:

Synonyms:(1'R,2'S)-(2'-Dimethylamino-1'-phenylpropyl) (4E)-3-(tert-butyldimethylsiloxy)-2,4-dimethylhex-4-enoate

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Chemical Property of (1'R,2'S)-(2'-Dimethylamino-1'-phenylpropyl) (4E)-3-(tert-butyldimethylsiloxy)-2,4-dimethylhex-4-enoate

Chemical Property:

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Technology Process of (1'R,2'S)-(2'-Dimethylamino-1'-phenylpropyl) (4E)-3-(tert-butyldimethylsiloxy)-2,4-dimethylhex-4-enoate

There total 8 articles about (1'R,2'S)-(2'-Dimethylamino-1'-phenylpropyl) (4E)-3-(tert-butyldimethylsiloxy)-2,4-dimethylhex-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 134833-53-7,134930-84-0
(1'R,2'S)-(2'-Dimethylamino-1'-phenylpropyl) (4E)-3-hydroxy-2,4-dimethylhex-4-enoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 138133-37-6
(1'R,2'S)-(2'-Dimethylamino-1'-phenylpropyl) (4E)-3-(tert-butyldimethylsiloxy)-2,4-dimethylhex-4-enoate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 63h; Ambient temperature;

Reference yield: 61.0%

: 134833-53-7
(E)-(2S,3R)-3-Hydroxy-2,4-dimethyl-hex-4-enoic acid (1R,2S)-2-dimethylamino-1-phenyl-propyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 138133-37-6
(E)-(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-hex-4-enoic acid (1R,2S)-2-dimethylamino-1-phenyl-propyl ester

Guidance literature:

Reference yield:

: 53135-04-9
(1R,2S)-(2-Dimethylamino-1-phenyl)propyl propanoate

: 138133-37-6
(1'R,2'S)-(2'-Dimethylamino-1'-phenylpropyl) (4E)-3-(tert-butyldimethylsiloxy)-2,4-dimethylhex-4-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran

1.2: tetrahydrofuran

2.1: TiCl₄

With titanium tetrachloride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/ja0632862