C₁₅H₂₀N₂O

Base Information

• Chemical Name: C₁₅H₂₀N₂O
• CAS No.: 1307856-74-1
• Molecular Formula: C₁₅H₂₀N₂O
• Molecular Weight: 244.337
• Mol file: 1307856-74-1.mol

Synonyms:C₁₅H₂₀N₂O

Chemical Property of C₁₅H₂₀N₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₂₀N₂O

There total 2 articles about C₁₅H₂₀N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

C15H22N2O2 (1307856-70-7) → C15H20N2O (1307856-74-1)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at -78 ℃; for 3h; Inert atmosphere;

DOI:10.1002/chem.201003424

Reference yield:

(2R)-1[(R)-α-methylbenzyl]-2-aziridinecarboxylate ethyl ester (68820-82-6) → C15H20N2O (1307856-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lanthanum(III) chloride; n-butyllithium / cyclohexane; toluene / 0.25 h / 0 - 30 °C / Inert atmosphere

1.2: 1 h / 30 °C / Inert atmosphere

2.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / -78 °C / Inert atmosphere

With lanthanum(III) chloride; n-butyllithium; diethylamino-sulfur trifluoride; In dichloromethane; cyclohexane; toluene;

DOI:10.1002/chem.201003424

Reference yield: 90.0%

C15H20N2O (1307856-74-1) + methyl iodide (74-88-4) → C16H22N2O (1307856-82-1)

Guidance literature:

C₁₅H₂₀N₂O; With n-butyllithium; In tetrahydrofuran; cyclohexane; at -98 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; cyclohexane; at -98 ℃; for 1h; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201003424

upstream raw materials:

C₁₅H₂₂N₂O₂

(2R)-1[(R)-α-methylbenzyl]-2-aziridinecarboxylate ethyl ester

Downstream raw materials:

C₁₅H₁₉⁽²⁾HN₂O

(1'R,2R)-butyl-1-(phenylethyl)aziridin-2-yl ketone

C₁₇H₂₄N₂O

C₁₆H₂₂N₂O