Piperidine,1-(cis-4-methyl-1-phenylcyclohexyl)-

Base Information

• Chemical Name: Piperidine,1-(cis-4-methyl-1-phenylcyclohexyl)-
• CAS No.: 29084-52-4
• Molecular Formula: C18H27 N
• Molecular Weight: 257.419
• Mol file: 29084-52-4.mol

Synonyms:Piperidine,1-(4-methyl-1-phenylcyclohexyl)-, cis-; Piperidine,1-(4-methyl-1-phenylcyclohexyl)-, stereoisomer (8CI); GK 4

Chemical Property of Piperidine,1-(cis-4-methyl-1-phenylcyclohexyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperidine,1-(cis-4-methyl-1-phenylcyclohexyl)-

There total 5 articles about Piperidine,1-(cis-4-methyl-1-phenylcyclohexyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-phenyl-1-piperidino-4-methylenecyclohexane (110915-02-1) → trans-Ph/Me 1-(1-phenyl-4-methylcyclohexyl)piperidine (29084-52-4) + cis-Ph/Me 1-(1-phenyl-4-methylcyclohexyl)piperidine (55040-03-4)

Guidance literature:

With hydrogen; nickel; In ethanol; for 16h; under 2068.6 Torr; Ambient temperature;

DOI:10.1016/S0040-4039(01)80977-1

Reference yield:

4-phenyl-4-(1-piperidinyl)cyclohexanone (65620-13-5) → trans-Ph/Me 1-(1-phenyl-4-methylcyclohexyl)piperidine (29084-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / n-BuLi / tetrahydrofuran

2: H₂ / Raney nickel / ethanol / 16 h / 2068.6 Torr / Ambient temperature; other catalyst

With n-butyllithium; hydrogen; nickel; In tetrahydrofuran; ethanol;

DOI:10.1016/S0040-4039(01)80977-1

Reference yield:

4-Phenyl-4-piperidinocyclohexanol (60756-83-4) → trans-Ph/Me 1-(1-phenyl-4-methylcyclohexyl)piperidine (29084-52-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) Jones reagent 2) sodium citrate, mossy Zn / 1) acetone

2: 87 percent / n-BuLi / tetrahydrofuran

3: H₂ / Raney nickel / ethanol / 16 h / 2068.6 Torr / Ambient temperature; other catalyst

With n-butyllithium; jones reagent; hydrogen; sodium citrate; zinc; nickel; In tetrahydrofuran; ethanol;

DOI:10.1016/S0040-4039(01)80977-1

upstream raw materials:

1,5-dibromo-pentane

4-Methyl-1-phenyl-cyclohexylamine

1-phenyl-1-piperidino-4-methylenecyclohexane

4-phenyl-4-(1-piperidinyl)cyclohexanone