65620-13-5

Basic information

• Product Name: Cyclohexanone, 4-phenyl-4-(1-piperidinyl)-
• CAS NO: 65620-13-5
• Molecular Formula: C17H23NO
• Molecular Weight: 257.376
• Mol File: 65620-13-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 4-phenyl-4-(1-piperidinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 4-phenyl-4-(1-piperidinyl)-(65620-13-5)
• EPA Substance Registry System: Cyclohexanone, 4-phenyl-4-(1-piperidinyl)-(65620-13-5)

Safety Data

• Hazardous Substances Data: 65620-13-5(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 65620-12-4 4-phenyl-4-(1-piperidinyl)cyclohexanone, ethylene ketal hydrochloride 
• 155604-21-0 8-Piperidin-1-yl-1,4-dioxa-spiro[4.5]decane-8-carbonitrile 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 60756-83-4 4-Phenyl-4-piperidinocyclohexanol 

Downstream Products

• 55040-03-4 cis-Ph/Me 1-(1-phenyl-4-methylcyclohexyl)piperidine 
• 29084-52-4 trans-Ph/Me 1-(1-phenyl-4-methylcyclohexyl)piperidine 
• 110915-02-1 1-phenyl-1-piperidino-4-methylenecyclohexane 

Relevant articles and documents

Discovery of a potent analgesic NOP and opioid receptor agonist: Cebranopadol

In a previous communication, our efforts leading from 1 to the identification of spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amine 2a as analgesic NOP and opioid receptor agonist were disclosed and their favorable in vitro and in vivo pharmacological properties revealed. We herein report our efforts to further optimize lead 2a, toward trans-6′-fluoro-4′, 9′-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1′(3′H) -pyrano[3,4-b]indol]-4-amine (cebranopadol, 3a), which is currently in clinical development for the treatment of severe chronic nociceptive and neuropathic pain.

Phencyclidine compounds and assays for its determination

Novel oxime derivatives of phencyclidine are provided as precursors for conjugating proteins, either antigenic for the preparation of antibodies or enzymatic for the preparation of enzyme conjugates, which antibodies and enzyme conjugates find use as reagents in immunoassays. The combination of antibodies and enzyme conjugates provide for sensitive, accurate, rapid assays for phencyclidine without interference from commonly administered drugs, such as dextromethorphan, demerol and chlorpromazine.