Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH

Base Information

Chemical Name:Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH
CAS No.:118171-89-4
Molecular Formula:C₄₉H₇₈N₄O₁₂Si
Molecular Weight:943.263
Hs Code.:

Synonyms:Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH

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Chemical Property of Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH

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Technology Process of Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH

There total 22 articles about Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 118206-77-2
Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OTce

: 118171-89-4
Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH

Guidance literature:: With ammonium acetate; zinc; In tetrahydrofuran; for 18h; Ambient temperature;
DOI:10.1021/ja00184a041

Reference yield:

: 118171-87-2
Boc-(R)-MeLeu-(S)-Thr(Bzl)-(3S,4R,5S)-Ist(TBDMS)-OTce

: 118171-89-4
Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / H₂ / Pd/C / tetrahydrofuran / 1.5 h / 760 Torr / Ambient temperature

2: 79 percent / DCC, DMAP / CH₂Cl₂ / 24 h / Ambient temperature

3: 66 percent / Zn, aq. NH₄OAc / tetrahydrofuran / 24 h

With dmap; ammonium acetate; hydrogen; dicyclohexyl-carbodiimide; zinc; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo961932h

Reference yield:

: 16937-99-8,53296-34-7
N-Boc-D-Leu

: 118171-89-4
Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / tetrahydrofuran

2: 83 percent / DEPC, Et₃N / dimethylformamide / 0 deg C, 4 h, then r.t., 19 h

3: 72 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

4: 99 percent / H₂ / 5percent Pd-C / tetrahydrofuran / 3 h / Ambient temperature

5: 100 percent / DMAP, DCC / CH₂Cl₂ / 0 deg C, 3 h, then r.t., 22 h

6: 89 percent / Zn, 1M aq. NH₄OAc / tetrahydrofuran / 18 h / Ambient temperature

With 1H-imidazole; dmap; ammonium acetate; hydrogen; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; diethyl dicarbonate; zinc; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00184a041