(3-O-benzyl-17β-O(tert-butyldimethylsilyl)estradiol)-β-tricarbonylchromium

Base Information

Chemical Name:(3-O-benzyl-17β-O(tert-butyldimethylsilyl)estradiol)-β-tricarbonylchromium
CAS No.:88765-18-8
Molecular Formula:C₃₄H₄₄CrO₅Si
Molecular Weight:612.802
Hs Code.:

Synonyms:(3-O-benzyl-17β-O(tert-butyldimethylsilyl)estradiol)-β-tricarbonylchromium

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Chemical Property of (3-O-benzyl-17β-O(tert-butyldimethylsilyl)estradiol)-β-tricarbonylchromium

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Technology Process of (3-O-benzyl-17β-O(tert-butyldimethylsilyl)estradiol)-β-tricarbonylchromium

There total 1 articles about (3-O-benzyl-17β-O(tert-butyldimethylsilyl)estradiol)-β-tricarbonylchromium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 98757-32-5
β-(3-(benzyloxy)-17β-hydroxyestra-1,3,5(10)-triene)tricarbonylchromium

: 18162-48-6
tert-butyldimethylsilyl chloride

: 88765-18-8
(3-O-benzyl-17β-O(tert-butyldimethylsilyl)estradiol)-β-tricarbonylchromium

Guidance literature:: With sodium hydride; In tetrahydrofuran; a THF soln. of Cr-complex was carefully added under N2 to a suspn. of 50% NaH in THF, mixt. was stirred overnight at ambient temp., heated under reflux during 2 h, t-BuMe2SiCl was added, temp. was maintained for another 2.5 h; hydrolyzed with ice water, extd. with ether, ext. was evapd., residue chromd. on a SiO2 column (eluent ether-petroleum ether);

Reference yield: 62.0%

: 88765-18-8
(3-O-benzyl-17β-O(tert-butyldimethylsilyl)estradiol)-β-tricarbonylchromium

: 88765-19-9
Cr(CO)3C₆H₃(OCH₂C₆H₅)(CH(CH₂OH)CH₂)CHCHCH₂CH₂C(CH₃)CH(OSi(CH₃)2C(CH₃)3)CH₂CH₂CH

Guidance literature:: With hydrogenchloride; formaldehyd; sodium hexamethyldisilazane; In dimethyl sulfoxide; (Ar); soln. of Cr complex and NaN(SiMe3)2 was stirred at 40°C for 5 min, to mixt. was added formaldehyde at room temp., after 2 h was hydrolyzed with aq. HCl; mixt. was extd. with ether and chromd. (silicagel, ether/petroleum ether 1/1); recrystn. from ether/petroleum ether;
DOI:10.1021/ja00319a049