(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanol

Base Information

• Chemical Name: (4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanol
• CAS No.: 1204243-69-5
• Molecular Formula: C₁₇H₁₅FN₆O
• Molecular Weight: 338.344

Synonyms:(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanol

Chemical Property of (4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanol

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Technology Process of (4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanol

There total 1 articles about (4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanone (1204243-68-4) → (4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanol (1204243-69-5)

Guidance literature:

With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 2h; Product distribution / selectivity;

Reference yield: 72.0%

(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanol (1204243-69-5) → [2-(4-fluorobenzyl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-(5-methyl-1H-pyrazol-3-yl)amine (1204244-76-7)

Guidance literature:

With triethylsilane; methanesulfonic acid; In trifluoroacetic acid; at 0 - 40 ℃;

Reference yield: 69.0%

(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanol (1204243-69-5) + 2-chloro-ethanol (107-07-3) → 2-((2-chloroethoxy)(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (1204246-30-9)

Guidance literature:

With methanesulfonic acid; at 140 ℃; for 0.666667h; Product distribution / selectivity; Microwave irradiation;

upstream raw materials:

(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanone

Downstream raw materials:

2-((2-chloroethoxy)(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

2-((4-fluorophenyl)(2-methoxyethoxy)methyl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

2-(fluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

2-(bromo(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

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