2-[4-(3-{1-[4-(6-amino-2-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

Base Information

• Chemical Name: 2-[4-(3-{1-[4-(6-amino-2-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide
• CAS No.: 1360551-66-1
• Molecular Formula: C₂₅H₂₆FN₇O₂
• Molecular Weight: 475.526
• Mol file: 1360551-66-1.mol

Synonyms:2-[4-(3-{1-[4-(6-amino-2-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

Chemical Property of 2-[4-(3-{1-[4-(6-amino-2-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(3-{1-[4-(6-amino-2-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

There total 4 articles about 2-[4-(3-{1-[4-(6-amino-2-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H24F2N6O2 (1360553-37-2) → 2-[4-(3-{1-[4-(6-amino-2-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide (1360551-66-1) + 2-[4-(3-{1-[4-(2-amino-6-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide (1360551-65-0)

Guidance literature:

With ammonia; In methanol; at 100 ℃; for 72h;

Reference yield:

C12H15BrN2O (1360551-94-5) → 2-[4-(3-{1-[4-(6-amino-2-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide (1360551-66-1) + 2-[4-(3-{1-[4-(2-amino-6-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide (1360551-65-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / 1,4-dioxane / 0.5 h / 50 °C

1.2: 48 h / 85 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 1 h / 100 °C / microwave

4.1: ammonia / methanol / 72 h / 100 °C

With ammonia; sodium carbonate; potassium carbonate; 1,1'-carbonyldiimidazole; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

3-[1-(4-bromo-phenyl)-1-cyclopropyl-ethyl]-5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazole (1360552-33-5) → 2-[4-(3-{1-[4-(6-amino-2-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide (1360551-66-1) + 2-[4-(3-{1-[4-(2-amino-6-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide (1360551-65-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 1 h / 100 °C / microwave

3: ammonia / methanol / 72 h / 100 °C

With ammonia; sodium carbonate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

3-[1-(4-bromo-phenyl)-1-cyclopropyl-ethyl]-5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazole

2-(4-{3-[1-(4-bromo-phenyl)-1-cyclopropyl-ethyl]-[1,2,4]oxadiazol-5-yl}-pyrazol-1-yl)-N,N-dimethyl-acetamide

C₂₅H₂₄F₂N₆O₂

C₁₂H₁₅BrN₂O