2-[4-(3-{1-[4-(2-amino-6-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

Base Information

Chemical Name:2-[4-(3-{1-[4-(2-amino-6-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide
CAS No.:1360551-65-0
Molecular Formula:C₂₅H₂₆FN₇O₂
Molecular Weight:475.526
Hs Code.:

Synonyms:2-[4-(3-{1-[4-(2-amino-6-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

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Chemical Property of 2-[4-(3-{1-[4-(2-amino-6-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

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Technology Process of 2-[4-(3-{1-[4-(2-amino-6-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

There total 4 articles about 2-[4-(3-{1-[4-(2-amino-6-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360553-37-2
C₂₅H₂₄F₂N₆O₂

: 1360551-66-1
2-[4-(3-{1-[4-(6-amino-2-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

: 1360551-65-0
2-[4-(3-{1-[4-(2-amino-6-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

Guidance literature:: With ammonia; In methanol; at 100 ℃; for 72h;

Reference yield:

: 1360551-94-5
C₁₂H₁₅BrN₂O

: 1360551-66-1
2-[4-(3-{1-[4-(6-amino-2-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

: 1360551-65-0
2-[4-(3-{1-[4-(2-amino-6-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / 1,4-dioxane / 0.5 h / 50 °C

1.2: 48 h / 85 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 1 h / 100 °C / microwave

4.1: ammonia / methanol / 72 h / 100 °C

With ammonia; sodium carbonate; potassium carbonate; 1,1'-carbonyldiimidazole; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1360552-33-5
3-[1-(4-bromo-phenyl)-1-cyclopropyl-ethyl]-5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazole

: 1360551-66-1
2-[4-(3-{1-[4-(6-amino-2-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

: 1360551-65-0
2-[4-(3-{1-[4-(2-amino-6-fluoropyridin-3-yl)phenyl]-1-cyclopropylethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 1 h / 100 °C / microwave

3: ammonia / methanol / 72 h / 100 °C

With ammonia; sodium carbonate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;