(4R,5S)-3-ethoxycarbonyl-4-hydroxy-5-[(S)-hydroxyphenylmethyl]-4,5-dihydroisoxazole 2-oxide

Base Information

Chemical Name:(4R,5S)-3-ethoxycarbonyl-4-hydroxy-5-[(S)-hydroxyphenylmethyl]-4,5-dihydroisoxazole 2-oxide
CAS No.:332080-22-5
Molecular Formula:C₁₃H₁₅NO₆
Molecular Weight:281.265
Hs Code.:

Synonyms:(4R,5S)-3-ethoxycarbonyl-4-hydroxy-5-[(S)-hydroxyphenylmethyl]-4,5-dihydroisoxazole 2-oxide

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Chemical Property of (4R,5S)-3-ethoxycarbonyl-4-hydroxy-5-[(S)-hydroxyphenylmethyl]-4,5-dihydroisoxazole 2-oxide

Chemical Property:

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Technology Process of (4R,5S)-3-ethoxycarbonyl-4-hydroxy-5-[(S)-hydroxyphenylmethyl]-4,5-dihydroisoxazole 2-oxide

There total 3 articles about (4R,5S)-3-ethoxycarbonyl-4-hydroxy-5-[(S)-hydroxyphenylmethyl]-4,5-dihydroisoxazole 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 626-35-7
nitroacetic acid ethyl ester

: 126720-47-6
(2R,3S)-3-phenyloxirane-2-carbaldehyde

: 332080-21-4
(4S,5S)-3-ethoxycarbonyl-4-hydroxy-5-[(S)-hydroxyphenylmethyl]-4,5-dihydroisoxazole 2-oxide

: 332080-22-5
(4R,5S)-3-ethoxycarbonyl-4-hydroxy-5-[(S)-hydroxyphenylmethyl]-4,5-dihydroisoxazole 2-oxide

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃;
DOI:10.1021/ol0070379

Reference yield:

: 626-35-7
nitroacetic acid ethyl ester

: 104196-23-8
(2S,3S)-2,3-epoxy-3-phenyl-1-propanol

: 332080-21-4
(4S,5S)-3-ethoxycarbonyl-4-hydroxy-5-[(S)-hydroxyphenylmethyl]-4,5-dihydroisoxazole 2-oxide

: 332080-22-5
(4R,5S)-3-ethoxycarbonyl-4-hydroxy-5-[(S)-hydroxyphenylmethyl]-4,5-dihydroisoxazole 2-oxide

Guidance literature:: With 1H-imidazole; 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; In 1,2-dichloro-ethane; at 20 ℃;
DOI:10.1021/ol0070379

Reference yield:

: 104196-23-8
(2S,3S)-2,3-epoxy-3-phenyl-1-propanol

: 332080-22-5
(4R,5S)-3-ethoxycarbonyl-4-hydroxy-5-[(S)-hydroxyphenylmethyl]-4,5-dihydroisoxazole 2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: bisacetoxyiodobenzene; tetramethylpiperidinyloxy radical / CH₂Cl₂ / 5 h / 20 °C

2: imidazole / CH₂Cl₂ / 20 °C

With 1H-imidazole; [bis(acetoxy)iodo]benzene; tetramethylpiperidinyloxy radical; In dichloromethane;
DOI:10.1021/ol0070379