6-methoxy-7-bromoestradiol

Base Information

• Chemical Name: 6-methoxy-7-bromoestradiol
• CAS No.: 115375-37-6
• Molecular Formula: C₁₉H₂₅BrO₃
• Molecular Weight: 381.31
• Mol file: 115375-37-6.mol

Synonyms:6b-Methoxy-7a-bromoestradiol

Chemical Property of 6-methoxy-7-bromoestradiol

Chemical Property:

• Vapor Pressure: 5.48E-11mmHg at 25°C
• Boiling Point: 504.2°Cat760mmHg
• Flash Point: 258.7°C
• PSA: 49.69000
• Density: 1.44g/cm³
• LogP: 4.12760

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-methoxy-7-bromoestradiol

There total 4 articles about 6-methoxy-7-bromoestradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6β-methoxy-7α-bromoestradiol 3-tetrahydropyranyl ether (115375-40-1) → 7α-bromo-1,3,5(10)-estratriene-3,6β,17β-triol 6-methyl ether (115375-37-6)

Guidance literature:

With hydrogenchloride; In methanol; for 0.5h; Yield given; Ambient temperature;

DOI:10.1016/0039-128X(86)90025-5

Reference yield:

6-dehydroestrone (2208-12-0) → 7α-bromo-1,3,5(10)-estratriene-3,6β,17β-triol 6-methyl ether (115375-37-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / p-TosOH*H₂O / CH₂Cl₂ / 2 h / Ambient temperature

2: 99 percent / LiAl(OtBu)3H / tetrahydrofuran / 12 h / Ambient temperature

3: NaBr, NCS / 0.5 h / Ambient temperature

4: conc. HCl / methanol / 0.5 h / Ambient temperature

With hydrogenchloride; N-chloro-succinimide; toluene-4-sulfonic acid; lithium tri-t-butoxyaluminum hydride; sodium bromide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/0039-128X(86)90025-5

Reference yield:

1,3,5(10),6-estratetraene-3,17β-diol 3-tetrahydropyranyl ether (115375-39-8) → 7α-bromo-1,3,5(10)-estratriene-3,6β,17β-triol 6-methyl ether (115375-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBr, NCS / 0.5 h / Ambient temperature

2: conc. HCl / methanol / 0.5 h / Ambient temperature

With hydrogenchloride; N-chloro-succinimide; sodium bromide; In methanol;

DOI:10.1016/0039-128X(86)90025-5

upstream raw materials:

6β-methoxy-7α-bromoestradiol 3-tetrahydropyranyl ether

6-dehydroestrone

1,3,5(10),6-estratetraene-3,17β-diol 3-tetrahydropyranyl ether

3-hydroxy-1,3,5⁽¹⁰⁾,6-estratetraen-17-one 3-tetrahydropyranyl ether

Refernces