N-[7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl]acetamide

Base Information

Chemical Name:N-[7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl]acetamide
CAS No.:1333213-67-4
Molecular Formula:C₂₇H₂₇FN₆O₄S
Molecular Weight:550.614
Hs Code.:

Synonyms:N-[7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl]acetamide

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Chemical Property of N-[7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl]acetamide

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Technology Process of N-[7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl]acetamide

There total 9 articles about N-[7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1333214-17-7
7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-sulfonamide

: 75-36-5
acetyl chloride

: 1333213-67-4
N-[7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl]acetamide

Guidance literature:: With dmap; In pyridine; at 50 ℃; for 2h;

Reference yield:

: 1333214-12-2
ethyl 7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylate

: 1333213-67-4
N-[7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl]acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: chlorosulfonic acid / dichloromethane / 20 °C

2.1: thionyl chloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 2 h / Reflux

3.1: triethylamine / dichloromethane / 2 h / 20 °C / Reflux

4.1: sodium hydroxide / ethanol; water / 4 h / 80 °C

4.2: pH 1 / Cooling with ice

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

6.1: trifluoroacetic acid / 20 °C

7.1: dmap / pyridine / 2 h / 50 °C

With chlorosulfonic acid; dmap; thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In pyridine; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1333214-13-3
6-ethoxycarbonyl-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-3-sulfonic acid

: 1333213-67-4
N-[7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl]acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 2 h / Reflux

2.1: triethylamine / dichloromethane / 2 h / 20 °C / Reflux

3.1: sodium hydroxide / ethanol; water / 4 h / 80 °C

3.2: pH 1 / Cooling with ice

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

5.1: trifluoroacetic acid / 20 °C

6.1: dmap / pyridine / 2 h / 50 °C

With dmap; thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In pyridine; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;