S-(-)-2β-{[4-(4'-aminophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

Base Information

Chemical Name:S-(-)-2β-{[4-(4'-aminophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane
CAS No.:914955-91-2
Molecular Formula:C₃₂H₃₆F₂N₂O₃
Molecular Weight:534.646
Hs Code.:

Synonyms:S-(-)-2β-{[4-(4'-aminophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of S-(-)-2β-{[4-(4'-aminophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

Chemical Property:

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Technology Process of S-(-)-2β-{[4-(4'-aminophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

There total 5 articles about S-(-)-2β-{[4-(4'-aminophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 156774-35-5
O 620

: 914955-91-2
S-(-)-2β-{[4-(4'-aminophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / LiAlH₄ / diethyl ether / 3 h / 0 - 20 °C

2.1: SOCl₂ / 3 h / Heating

2.2: 87 percent / triethylamine / CH₂Cl₂ / 3 h / 0 - 20 °C

3.1: H₂ / Raney Ni / H₂O; methanol; ethyl acetate / 1551.44 Torr

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; nickel; In methanol; diethyl ether; water; ethyl acetate;
DOI:10.1021/jm060762q

Reference yield:

: 914955-90-1
S-(+)-2β-{[4-(4'-nitrophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

: 914955-91-2
S-(-)-2β-{[4-(4'-aminophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

Guidance literature:: With hydrogen; nickel; In methanol; water; ethyl acetate; under 1551.44 Torr;
DOI:10.1021/jm060762q

Reference yield:

: 914955-85-4
S-(+)-2β-hydroxymethyl-3α-[bis(4-fluorophenyl)methoxy]tropane

: 914955-91-2
S-(-)-2β-{[4-(4'-aminophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

Guidance literature:: Multi-step reaction with 2 steps

1.1: SOCl₂ / 3 h / Heating

1.2: 87 percent / triethylamine / CH₂Cl₂ / 3 h / 0 - 20 °C

2.1: H₂ / Raney Ni / H₂O; methanol; ethyl acetate / 1551.44 Torr

With thionyl chloride; hydrogen; nickel; In methanol; water; ethyl acetate;
DOI:10.1021/jm060762q